Association of human papillomavirus types 16 and 18 E6 proteins with p53
- PMID: 2157286
- DOI: 10.1126/science.2157286
Association of human papillomavirus types 16 and 18 E6 proteins with p53
Abstract
Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human anogenital cancers and encodes two transforming proteins, E6 and E7. The E7 protein has been shown to bind to the retinoblastoma tumor suppressor gene product, pRB. This study shows that the E6 protein of HPV-16 is capable of binding to the cellular p53 protein. The ability of the E6 proteins from different human papillomaviruses to form complexes with p53 was assayed and found to correlate with the in vivo clinical behavior and the in vitro transforming activity of these different papillomaviruses. The wild-type p53 protein has tumor suppressor properties and has also been found in association with large T antigen and the E1B 55-kilodalton protein in cells transformed by SV40 and by adenovirus type 5, respectively, providing further evidence that the human papillomaviruses, the adenoviruses, and SV40 may effect similar cellular pathways in transformation.
Similar articles
-
Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions.J Virol. 1994 May;68(5):2811-21. doi: 10.1128/JVI.68.5.2811-2821.1994. J Virol. 1994. PMID: 8151752 Free PMC article.
-
Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.EMBO J. 1992 Aug;11(8):3045-52. doi: 10.1002/j.1460-2075.1992.tb05375.x. EMBO J. 1992. PMID: 1379175 Free PMC article.
-
Cellular targets of the oncoproteins encoded by the cancer associated human papillomaviruses.Princess Takamatsu Symp. 1991;22:239-48. Princess Takamatsu Symp. 1991. PMID: 1668886 Review.
-
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.Proc Natl Acad Sci U S A. 1992 May 15;89(10):4549-53. doi: 10.1073/pnas.89.10.4549. Proc Natl Acad Sci U S A. 1992. PMID: 1316611 Free PMC article.
-
Human papillomavirus E6 and E7: proteins which deregulate the cell cycle.Bioessays. 1995 Jun;17(6):509-18. doi: 10.1002/bies.950170607. Bioessays. 1995. PMID: 7575492 Review.
Cited by
-
Management for persistent HPV infection and cervical lesions among women infected with HIV: a retrospective observational cohort study.Virol J. 2024 Jun 6;21(1):133. doi: 10.1186/s12985-024-02405-y. Virol J. 2024. PMID: 38844960 Free PMC article.
-
From Satirical Poems and Invisible Poisons to Radical Surgery and Organized Cervical Cancer Screening-A Historical Outline of Cervical Carcinoma and Its Relation to HPV Infection.Life (Basel). 2024 Feb 27;14(3):307. doi: 10.3390/life14030307. Life (Basel). 2024. PMID: 38541633 Free PMC article. Review.
-
Structure of the p53 degradation complex from HPV16.Nat Commun. 2024 Feb 28;15(1):1842. doi: 10.1038/s41467-024-45920-w. Nat Commun. 2024. PMID: 38418456 Free PMC article.
-
The Hallmarks of Cervical Cancer: Molecular Mechanisms Induced by Human Papillomavirus.Biology (Basel). 2024 Jan 27;13(2):77. doi: 10.3390/biology13020077. Biology (Basel). 2024. PMID: 38392296 Free PMC article. Review.
-
MmuPV1 E6 induces cell proliferation and other hallmarks of cancer.mBio. 2023 Dec 19;14(6):e0245823. doi: 10.1128/mbio.02458-23. Epub 2023 Oct 31. mBio. 2023. PMID: 37905801 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous