[Research progress on mechanism of antimicrobial peptides]
- PMID: 21595181
[Research progress on mechanism of antimicrobial peptides]
Abstract
The antimicrobial peptide is a class of small molecule peptide derived from a variety of creatures, able to kill the pathogens efficiently and has the potential of broad-spectrum activity, rapid and strong bactericidal activity, low propensity for resistance development, and many other advantages. As a new generation of anti-infective drug candidates, the mechanism of antimicrobial peptides has not yet entirely clear, but now there are two views have been widely recognized that the destruction of permeation through the membrane structural integrity and through the different intracellular target to affect bacterium growth and metabolic balance. In this paper, the physical and chemical properties, secondary structure, mechanism, and the relationship between the latter two to make a conclusion, in order to better understand the structure-activity relationships and to provide a theoretical basis for rational design of antimicrobial peptides.
Similar articles
-
Optimizing antimicrobial host defense peptides.Chem Biol. 2006 Oct;13(10):1015-7. doi: 10.1016/j.chembiol.2006.10.001. Chem Biol. 2006. PMID: 17052605
-
The expanding scope of antimicrobial peptide structures and their modes of action.Trends Biotechnol. 2011 Sep;29(9):464-72. doi: 10.1016/j.tibtech.2011.05.001. Epub 2011 Jun 15. Trends Biotechnol. 2011. PMID: 21680034 Review.
-
Alternative mechanisms of action of cationic antimicrobial peptides on bacteria.Expert Rev Anti Infect Ther. 2007 Dec;5(6):951-9. doi: 10.1586/14787210.5.6.951. Expert Rev Anti Infect Ther. 2007. PMID: 18039080 Review.
-
Advances in antimicrobial peptide immunobiology.Biopolymers. 2006;84(5):435-58. doi: 10.1002/bip.20543. Biopolymers. 2006. PMID: 16736494 Review.
-
Methods for building quantitative structure-activity relationship (QSAR) descriptors and predictive models for computer-aided design of antimicrobial peptides.Methods Mol Biol. 2010;618:77-86. doi: 10.1007/978-1-60761-594-1_6. Methods Mol Biol. 2010. PMID: 20094859
Cited by
-
Some research advances of immune mechanism during infection in China.Sci China Life Sci. 2011 Dec;54(12):1153-5. doi: 10.1007/s11427-011-4258-7. Epub 2012 Jan 7. Sci China Life Sci. 2011. PMID: 22227909 Free PMC article. Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials