Postinitiation transcriptional control in Drosophila melanogaster
- PMID: 2172790
- PMCID: PMC361402
- DOI: 10.1128/mcb.10.11.6041-6045.1990
Postinitiation transcriptional control in Drosophila melanogaster
Abstract
Drosophila hsp70 genes have an RNA polymerase II molecule paused at their 5' ends in uninduced cells. In this study we have shown that this pausing also occurs on other heat shock and constitutively expressed genes. We propose that a rate-limiting step in early elongation occurs in many Drosophila genes and may be a target for transcriptional regulation.
Similar articles
-
[Mechanism of transcription regulation by RNA polymerase II pausing].Tsitologiia. 2013;55(3):153-8. Tsitologiia. 2013. PMID: 23795456 Review. Russian.
-
The heat shock response: A case study of chromatin dynamics in gene regulation.Biochem Cell Biol. 2013 Feb;91(1):42-8. doi: 10.1139/bcb-2012-0075. Epub 2013 Feb 13. Biochem Cell Biol. 2013. PMID: 23442140 Review.
-
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila.Genes Dev. 2003 Jun 1;17(11):1402-14. doi: 10.1101/gad.1091403. Genes Dev. 2003. PMID: 12782658 Free PMC article.
-
In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes.Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7923-7. doi: 10.1073/pnas.90.17.7923. Proc Natl Acad Sci U S A. 1993. PMID: 8367444 Free PMC article.
-
RNA polymerase II pauses at the 5' end of the transcriptionally induced Drosophila hsp70 gene.Mol Cell Biol. 1991 Oct;11(10):5285-90. doi: 10.1128/mcb.11.10.5285-5290.1991. Mol Cell Biol. 1991. PMID: 1922045 Free PMC article.
Cited by
-
SilenceREIN: seeking silencers on anchors of chromatin loops by deep graph neural networks.Brief Bioinform. 2023 Nov 22;25(1):bbad494. doi: 10.1093/bib/bbad494. Brief Bioinform. 2023. PMID: 38168841 Free PMC article.
-
Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells.Nucleic Acids Res. 2023 Nov 27;51(21):e106. doi: 10.1093/nar/gkad843. Nucleic Acids Res. 2023. PMID: 37889042 Free PMC article.
-
The chromatin remodeler Ino80 mediates RNAPII pausing site determination.Genome Biol. 2021 Oct 18;22(1):294. doi: 10.1186/s13059-021-02500-1. Genome Biol. 2021. PMID: 34663418 Free PMC article.
-
cis Elements that Mediate RNA Polymerase II Pausing Regulate Human Gene Expression.Am J Hum Genet. 2019 Oct 3;105(4):677-688. doi: 10.1016/j.ajhg.2019.08.003. Epub 2019 Sep 5. Am J Hum Genet. 2019. PMID: 31495490 Free PMC article.
-
Environmental influence on Pristionchus pacificus mouth form through different culture methods.Sci Rep. 2017 Aug 3;7(1):7207. doi: 10.1038/s41598-017-07455-7. Sci Rep. 2017. PMID: 28775277 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases