Ezogabine (retigabine)
- PMID: 21959281
- DOI: 10.1038/nrd3561
Ezogabine (retigabine)
Abstract
Ezogabine (Potiga; Valeant Pharmaceuticals/GlaxoSmithKline), a potassium channel opener, was approved in June 2011 by the U.S. Food and Drug Administration (F.D.A.) for the adjunctive treatment of partial-onset seizures in adult patients. The same drug was granted marketing authorization for this indication in the European Union in March 2011, where it is known as retigabine (Trobalt).
Similar articles
-
Retigabine for partial onset seizures.Expert Rev Neurother. 2012 May;12(5):509-17. doi: 10.1586/ern.12.33. Expert Rev Neurother. 2012. PMID: 22550979 Review.
-
Ezogabine: development and role in the management of epileptic seizures.Mini Rev Med Chem. 2013 Apr 1;13(5):697-705. doi: 10.2174/1389557511313050006. Mini Rev Med Chem. 2013. PMID: 22931529 Review.
-
Ezogabine (retigabine) and its role in the treatment of partial-onset seizures: a review.Clin Ther. 2012 Sep;34(9):1845-56.e1. doi: 10.1016/j.clinthera.2012.07.009. Epub 2012 Aug 21. Clin Ther. 2012. PMID: 22917854 Review.
-
Efficacy and tolerability exposure-response relationship of retigabine (ezogabine) immediate-release tablets in patients with partial-onset seizures.Clin Ther. 2013 Aug;35(8):1174-1185.e4. doi: 10.1016/j.clinthera.2013.06.012. Epub 2013 Aug 1. Clin Ther. 2013. PMID: 23916044 Clinical Trial.
-
ACS chemical neuroscience molecule spotlight on Potiga (Ezogabine).ACS Chem Neurosci. 2012 Aug 15;3(8):632. doi: 10.1021/cn3000789. ACS Chem Neurosci. 2012. PMID: 22896808 Free PMC article. Review.
Cited by
-
The Formation and Function of the VTA Dopamine System.Int J Mol Sci. 2024 Mar 30;25(7):3875. doi: 10.3390/ijms25073875. Int J Mol Sci. 2024. PMID: 38612683 Free PMC article. Review.
-
A small-molecule activation mechanism that directly opens the KCNQ2 channel.Nat Chem Biol. 2024 Jul;20(7):847-856. doi: 10.1038/s41589-023-01515-y. Epub 2024 Jan 2. Nat Chem Biol. 2024. PMID: 38167918
-
Three-Step Synthesis of the Antiepileptic Drug Candidate Pynegabine.Molecules. 2023 Jun 21;28(13):4888. doi: 10.3390/molecules28134888. Molecules. 2023. PMID: 37446549 Free PMC article.
-
Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine.Sci Adv. 2022 Jul 22;8(29):eabo3625. doi: 10.1126/sciadv.abo3625. Epub 2022 Jul 20. Sci Adv. 2022. PMID: 35857840 Free PMC article.
-
Alternative Targets for Modulators of Mitochondrial Potassium Channels.Molecules. 2022 Jan 4;27(1):299. doi: 10.3390/molecules27010299. Molecules. 2022. PMID: 35011530 Free PMC article. Review.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources