Micronutrient special issue: coenzyme Q(10) requirements for DNA damage prevention
- PMID: 21964355
- DOI: 10.1016/j.mrfmmm.2011.09.004
Micronutrient special issue: coenzyme Q(10) requirements for DNA damage prevention
Abstract
Coenzyme Q(10) (CoQ(10)) is an essential component for electron transport in the mitochondrial respiratory chain and serves as cofactor in several biological processes. The reduced form of CoQ(10) (ubiquinol, Q(10)H(2)) is an effective antioxidant in biological membranes. During the last years, particular interest has been grown on molecular effects of CoQ(10) supplementation on mechanisms related to DNA damage prevention. This review describes recent advances in our understanding about the impact of CoQ(10) on genomic stability in cells, animals and humans. With regard to several in vitro and in vivo studies, CoQ(10) provides protective effects on several markers of oxidative DNA damage and genomic stability. In comparison to the number of studies reporting preventive effects of CoQ(10) on oxidative stress biomarkers, CoQ(10) intervention studies in humans with a direct focus on markers of DNA damage are limited. Thus, more well-designed studies in healthy and disease populations with long-term follow up results are needed to substantiate the reported beneficial effects of CoQ(10) on prevention of DNA damage.
Copyright © 2011 Elsevier B.V. All rights reserved.
Similar articles
-
Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients.J Psychiatr Res. 2012 Mar;46(3):341-5. doi: 10.1016/j.jpsychires.2011.11.002. Epub 2011 Nov 26. J Psychiatr Res. 2012. PMID: 22118833
-
Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?Biofactors. 2011 Sep-Oct;37(5):386-92. doi: 10.1002/biof.184. Biofactors. 2011. PMID: 22009852 Review.
-
Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells.J Nutr Biochem. 2009 May;20(5):350-7. doi: 10.1016/j.jnutbio.2008.04.005. Epub 2008 Jul 7. J Nutr Biochem. 2009. PMID: 18602819
-
Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress.Clin Chim Acta. 2005 Oct;360(1-2):87-96. doi: 10.1016/j.cccn.2005.04.009. Clin Chim Acta. 2005. PMID: 15935338
-
Biochemical and physiological aspects of ubiquinone function.Membr Cell Biol. 2000;13(5):595-602. Membr Cell Biol. 2000. PMID: 10987383 Review.
Cited by
-
The pleiotropic functions of reactive oxygen species in cancer.Nat Cancer. 2024 Mar;5(3):384-399. doi: 10.1038/s43018-024-00738-9. Epub 2024 Mar 22. Nat Cancer. 2024. PMID: 38531982 Review.
-
The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery.Int J Mol Sci. 2021 Aug 6;22(16):8463. doi: 10.3390/ijms22168463. Int J Mol Sci. 2021. PMID: 34445167 Free PMC article. Review.
-
Genotoxic risk in humans and acute toxicity in rats of a novel oral high-dose coenzyme Q10 oleogel.Toxicol Rep. 2021 Jun 16;8:1229-1239. doi: 10.1016/j.toxrep.2021.06.012. eCollection 2021. Toxicol Rep. 2021. PMID: 34195014 Free PMC article.
-
Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.Sci Rep. 2017 Aug 15;7(1):8253. doi: 10.1038/s41598-017-08899-7. Sci Rep. 2017. PMID: 28811612 Free PMC article.
-
Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects.Biofactors. 2015 Nov-Dec;41(6):383-90. doi: 10.1002/biof.1239. Epub 2015 Dec 9. Biofactors. 2015. PMID: 26648450 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
