Autophagy: renovation of cells and tissues
- PMID: 22078875
- DOI: 10.1016/j.cell.2011.10.026
Autophagy: renovation of cells and tissues
Abstract
Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the lysosome. However, the purpose of autophagy is not the simple elimination of materials, but instead, autophagy serves as a dynamic recycling system that produces new building blocks and energy for cellular renovation and homeostasis. Here we provide a multidisciplinary review of our current understanding of autophagy's role in metabolic adaptation, intracellular quality control, and renovation during development and differentiation. We also explore how recent mouse models in combination with advances in human genetics are providing key insights into how the impairment or activation of autophagy contributes to pathogenesis of diverse diseases, from neurodegenerative diseases such as Parkinson disease to inflammatory disorders such as Crohn disease.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment in
-
Macroautophagy without LC3 conjugation?Cell Res. 2017 Jan;27(1):5-6. doi: 10.1038/cr.2016.143. Epub 2016 Dec 6. Cell Res. 2017. PMID: 27922618 Free PMC article.
Similar articles
-
Autophagy: A Friend or Foe in Allergic Asthma?Int J Mol Sci. 2021 Jun 12;22(12):6314. doi: 10.3390/ijms22126314. Int J Mol Sci. 2021. PMID: 34204710 Free PMC article. Review.
-
Autophagy and Human Neurodegenerative Diseases-A Fly's Perspective.Int J Mol Sci. 2017 Jul 23;18(7):1596. doi: 10.3390/ijms18071596. Int J Mol Sci. 2017. PMID: 28737703 Free PMC article. Review.
-
Why autophagy is good for retinal ganglion cells?Eye (Lond). 2017 Feb;31(2):185-190. doi: 10.1038/eye.2016.278. Epub 2016 Dec 16. Eye (Lond). 2017. PMID: 27983732 Free PMC article. Review.
-
Autophagy and the kidney: health and disease.Nephrol Dial Transplant. 2014 Sep;29(9):1639-47. doi: 10.1093/ndt/gft535. Epub 2014 Feb 10. Nephrol Dial Transplant. 2014. PMID: 24520117 Review.
-
Autophagy contributes to lysosomal storage disorders.Autophagy. 2012 May 1;8(5):715-6. doi: 10.4161/auto.19920. Epub 2012 May 1. Autophagy. 2012. PMID: 22617443 Free PMC article.
Cited by
-
Myricetin Restores Autophagy to Attenuate Lumbar Intervertebral Disk Degeneration Via Negative Regulation of the JAK2/STAT3 Pathway.Biochem Genet. 2024 Jun 6. doi: 10.1007/s10528-024-10838-x. Online ahead of print. Biochem Genet. 2024. PMID: 38842745
-
Protective Effect of CXCR7 Against Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cells.Cell Biochem Biophys. 2024 May 28. doi: 10.1007/s12013-024-01312-x. Online ahead of print. Cell Biochem Biophys. 2024. PMID: 38806964
-
Chinese botanical drugs targeting mitophagy to alleviate diabetic kidney disease, a comprehensive review.Front Pharmacol. 2024 May 13;15:1360179. doi: 10.3389/fphar.2024.1360179. eCollection 2024. Front Pharmacol. 2024. PMID: 38803440 Free PMC article. Review.
-
A Proteomic Approach Identified TFEB as a Key Player in the Protective Action of Novel CB2R Bitopic Ligand FD22a against the Deleterious Effects Induced by β-Amyloid in Glial Cells.Cells. 2024 May 19;13(10):875. doi: 10.3390/cells13100875. Cells. 2024. PMID: 38786097 Free PMC article.
-
The Role of Autophagy in Vascular Endothelial Cell Health and Physiology.Cells. 2024 May 11;13(10):825. doi: 10.3390/cells13100825. Cells. 2024. PMID: 38786047 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases