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. 2011 Nov 25;50(48):11417-20.
doi: 10.1002/anie.201104449. Epub 2011 Oct 6.

Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration

Vikash P Chauhan  1 , Zoran Popović, Ou Chen, Jian Cui, Dai Fukumura, Moungi G Bawendi, Rakesh K Jain
Affiliations

Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration

Vikash P Chauhan et al. Angew Chem Int Ed Engl. .
No abstract available

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Figures

Figure 1
Figure 1
Nanospheres and nanorods designed for real-time in vivo imaging. a) Schematic representation of nanospheres and nanorods. The PEG layer is depicted as a gray glow. Dimensions obtained with TEM for the nanorod cores are shown (4.7 nm diameter and 44.0 length) as well as the approximate PEG-coated hydrodynamic lengths (15 nm diameter and 54 nm length). The hydrodynamic diameter range of the nanospheres and nanorods (obtained with DLS) is also shown (33–35 nm). b) TEM images of nanospheres and nanorods.
Figure 2
Figure 2
Transport rates in vitro for nanospheres versus nanorods of the same hydrodynamic diameter (33–35 nm). a) Diffusion rates across membranes with varied pore size, quantified as permeability. Both particles pass through micrometer-range pores at the same rate, while nanometer-range pores hinder the nanospheres more than the nanorods. b) Diffusion coefficients in 1% collagen gels. The nanorods diffuse 5.3-times as fast as the nanospheres (p =0.003, *).
Figure 3
Figure 3
Transport and distribution in tumors in vivo for nanospheres versus nanorods of the same hydrodynamic diameter (33–35 nm). a) Transvascular transport rates in orthotopic E0771 mammary tumors in mice. The nanorods are transported across vessel walls 4.1-times as fast as the nanospheres (p =0.03, *). b) Nanoparticle distribution in orthotopic E0771 mammary tumors in mice. The nanorods penetrate to 1.7 times the volume to which the nanospheres distribute (p =0.01, *). c) Nanoparticle penetration in tumors. Intensities are normalized to initial intravascular levels, and vessels are shown in black. The rods extravasate more and penetrate deeper than the spheres. Scale bar 100 μm.
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