Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Apr;13(3):232-8.
doi: 10.1038/gene.2011.82. Epub 2011 Dec 22.

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

C P Lin  1 , I Adrianto, C J Lessard, J A Kelly, K M Kaufman, J M Guthridge, B I Freedman, J-M Anaya, M E Alarcón-Riquelme; BIOLUPUS and GENLES Networks; B A Pons-Estel, J Martin, S Glenn, A Adler, S-C Bae, S-Y Park, S-Y Bang, Y-W Song, S A Boackle, E E Brown, J C Edberg, G S Alarcón, M A Petri, L A Criswell, R Ramsey-Goldman, J D Reveille, L M Vila, G S Gilkeson, D L Kamen, J Ziegler, C O Jacob, A Rasmussen, J A James, R P Kimberly, J T Merrill, T B Niewold, R H Scofield, A M Stevens, B P Tsao, T J Vyse, C D Langefeld, K L Moser, J B Harley, P M Gaffney, C G Montgomery
Collaborators, Affiliations

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

C P Lin et al. Genes Immun. 2012 Apr.

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N = 579) and African-Americans (AAs) (N = 407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P < 2.03 × 10(-3) were observed between LN and MYH9 in EAs (N = 4620), with the most pronounced association at rs2157257 (P = 4.7 × 10(-4), odds ratio (OR) = 1.205). A modest effect with MYH9 was also detected in Gullah (rs8136069, P = 0.0019, OR = 2.304). No association between LN and MYH9 was found in AAs, Asians, Amerindians or Hispanics. This study provides the first investigation of MYH9 in LN in non-Africans and of APOL1 in LN in any population, and presents novel insight into the potential role of MYH9 in LN in EAs.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement:

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Summary of association analysis for MYH9 SNPs
Plots of SNPs within the MYH9 gene associated with lupus nephritis in (a) European American, (b) African American and (c) Gullah populations. Genotyped SNPs are represented by circles and imputed SNPs are shown in rectangles. The recombination rate calculated from the combined CEU, YRI and JPT + CHB Hapmap data is denoted by the purple solid line. The dotted line refers to the Bonferroni threshold of significance.
Figure 2
Figure 2. The linkage disequilibrium for significant SNPs in European Americans
This plot shows the pair-wise LD between all markers given in the figure. SNPs in red box represent Effect 1 and SNPs in green box represent Effect 2. The intensities of the LD between SNPs are depicted in orange (Effect 1), green (Effect 2), and black (between Effect 1 and Effect 2).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hart HH, Grigor RR, Caughey DE. Ethnic difference in the prevalence of systemic lupus erythematosus. Ann Rheum Dis. 1983;42(5):529–532. - PMC - PubMed
    1. Bae SC, Fraser P, Liang MH. The epidemiology of systemic lupus erythematosus in populations of African ancestry: a critical review of the "prevalence gradient hypothesis". Arthritis Rheum. 1998;41(112):2091–2099. - PubMed
    1. Serdula MK, Rhoads GG. Frequency of systemic lupus erythematosus in different ethnic groups in Hawaii. Arthritis Rheum. 1979;22(4):328–333. - PubMed
    1. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25(11):1271–1277. - PubMed
    1. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40(9):1725. - PubMed

Publication types

MeSH terms

Grants and funding

-