Oxidative stress
- PMID: 22301329
- DOI: 10.1177/0148607111434963
Oxidative stress
Abstract
Oxidative stress is defined by an imbalance between increased levels of reactive oxygen species (ROS) and a low activity of antioxidant mechanisms. An increased oxidative stress can induce damage to the cellular structure and potentially destroy tissues. However, ROS are needed for adequate cell function, including the production of energy by the mitochondria. Increased oxidative stress has been incriminated in physiological conditions, such as aging and exercise, and in several pathological conditions, including cancer, neurodegenerative diseases, cardiovascular diseases, diabetes, inflammatory diseases, and intoxications. However, prevention by antioxidants has been mostly inefficient. Therefore, a rigorous scientific evaluation in well-defined conditions is mandatory to define the appropriate place for manipulations of the oxidative pathways in human medicine.
Similar articles
-
Tumor suppressor genes and ROS: complex networks of interactions.Free Radic Biol Med. 2012 Jan 1;52(1):7-18. doi: 10.1016/j.freeradbiomed.2011.09.035. Epub 2011 Oct 6. Free Radic Biol Med. 2012. PMID: 22019631 Review.
-
Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease.Cell Biochem Funct. 2011 Apr;29(3):183-206. doi: 10.1002/cbf.1737. Epub 2011 Mar 7. Cell Biochem Funct. 2011. PMID: 21381059
-
Free radicals, metals and antioxidants in oxidative stress-induced cancer.Chem Biol Interact. 2006 Mar 10;160(1):1-40. doi: 10.1016/j.cbi.2005.12.009. Epub 2006 Jan 23. Chem Biol Interact. 2006. PMID: 16430879 Review.
-
Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia.J Neurol Sci. 2005 Jun 15;233(1-2):145-62. doi: 10.1016/j.jns.2005.03.012. J Neurol Sci. 2005. PMID: 15896810 Review.
-
Exercise and oxidative stress: significance of antioxidants with reference to inflammatory, muscular, and systemic stress.Exerc Immunol Rev. 2001;7:108-33. Exerc Immunol Rev. 2001. PMID: 11579745 Review.
Cited by
-
Oxidative Metabolism in Brain Ischemia and Preconditioning: Two Sides of the Same Coin.Antioxidants (Basel). 2024 Apr 29;13(5):547. doi: 10.3390/antiox13050547. Antioxidants (Basel). 2024. PMID: 38790652 Free PMC article. Review.
-
Litchi Pericarp Extract Treats Type 2 Diabetes Mellitus by Regulating Oxidative Stress, Inflammatory Response, and Energy Metabolism.Antioxidants (Basel). 2024 Apr 21;13(4):495. doi: 10.3390/antiox13040495. Antioxidants (Basel). 2024. PMID: 38671942 Free PMC article.
-
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.Transl Androl Urol. 2023 Dec 31;12(12):1859-1870. doi: 10.21037/tau-23-543. Epub 2023 Dec 21. Transl Androl Urol. 2023. PMID: 38196697 Free PMC article.
-
Exploring the Role of Mediterranean and Westernized Diets and Their Main Nutrients in the Modulation of Oxidative Stress in the Placenta: A Narrative Review.Antioxidants (Basel). 2023 Oct 26;12(11):1918. doi: 10.3390/antiox12111918. Antioxidants (Basel). 2023. PMID: 38001771 Free PMC article. Review.
-
Saponins of Tomato Extract Improve Non-Alcoholic Fatty Liver Disease by Regulating Oxidative Stress and Lipid Homeostasis.Antioxidants (Basel). 2023 Oct 12;12(10):1848. doi: 10.3390/antiox12101848. Antioxidants (Basel). 2023. PMID: 37891927 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical