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Case Reports
. 2012 Mar;42(3):308-14.
doi: 10.1007/s00247-011-2268-z.

Rapidly involuting congenital haemangioma (RICH) of the liver

Derek Roebuck  1 , Neil Sebire, Eldon Lehmann, Alex Barnacle
Affiliations
Case Reports

Rapidly involuting congenital haemangioma (RICH) of the liver

Derek Roebuck et al. Pediatr Radiol. 2012 Mar.

Abstract

Background: Rapidly involuting congenital haemangioma (RICH) is a benign neoplasm that may occur in many locations in the body. When RICH occurs in the liver, it may be confused with other lesions.

Objective: To present a case series from a single institution.

Materials and methods: Retrospective review of pathological and imaging findings in infants with biopsy-proven hepatic RICH treated at a single hospital.

Results: Four children (2 days to 6 weeks of age) presented between 2002 and 2007 with a solitary hepatic lesion. Needle biopsy excluded the alternative possibility of infantile haemangioma by showing negativity for GLUT1. Serial imaging confirmed rapid involution in each child.

Conclusion: RICH should be suspected in neonates who present with a solitary liver lesion and normal-for-age serum alpha-fetoprotein. Serial US scans should be used to confirm a progressive shrinkage of the lesion. Corticosteroids and β2-adrenergic antagonists have no proven effect in treating RICH. If the lesion grows, percutaneous needle biopsy is recommended to exclude a malignant tumour and to direct further management. Infants with cardiac failure should be treated medically. Embolization (with or without needle biopsy) should only be performed when this strategy fails.

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References

    1. Pediatr Radiol. 2008 Jun;38 Suppl 3:S518-22 - PubMed
    1. Genes Chromosomes Cancer. 2002 Mar;33(3):295-303 - PubMed
    1. Pediatr Res. 1981 Jan;15(1):50-2 - PubMed
    1. Pediatr Hematol Oncol. 2006 Dec;23(8):639-47 - PubMed
    1. J Pediatr Surg. 2009 Jan;44(1):125-33 - PubMed

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