Screening for oesophageal cancer
- PMID: 22430857
- DOI: 10.1038/nrclinonc.2012.35
Screening for oesophageal cancer
Abstract
Oesophageal cancer is a global health problem with high mortality due to the advanced nature of the disease at presentation; therefore, detection at an early stage significantly improves outcome. Oesophageal squamous-cell cancer is preceded by dysplasia and oesophageal adenocarcinoma is preceded by Barrett's oesophagus, which progresses to cancer via intermediate dysplastic stages. Screening to detect these preneoplastic lesions has the potential to substantially reduce mortality and morbidity. However, the risks and benefits of such programmes to individuals and to society need to be carefully weighed. Endoscopic screening is invasive, costly and error prone owing to sampling bias and the subjective diagnosis of dysplasia. Non-endoscopic cell-sampling methods are less invasive and more cost effective than endoscopy, but the sensitivity and specificity of cytological assessment of atypia has been disappointing. The use of biomarkers to analyse samples collected using pan-oesophageal cell-collection devices may improve diagnostic accuracy; however, further work is required to confirm this. The psychological and economic implications of screening as well as the feasibility of implementing such programmes must also be considered.
Similar articles
-
Genetics and prevention of oesophageal adenocarcinoma.Recent Results Cancer Res. 2005;166:35-46. doi: 10.1007/3-540-26980-0_3. Recent Results Cancer Res. 2005. PMID: 15648181 Review.
-
Surveillance of Barrett's oesophagus: exploring the uncertainty through systematic review, expert workshop and economic modelling.Health Technol Assess. 2006 Mar;10(8):1-142, iii-iv. doi: 10.3310/hta10080. Health Technol Assess. 2006. PMID: 16545207 Review.
-
Should patients with Barrett's oesophagus be kept under surveillance? The case against.Best Pract Res Clin Gastroenterol. 2008;22(4):741-50. doi: 10.1016/j.bpg.2007.12.005. Best Pract Res Clin Gastroenterol. 2008. PMID: 18656827 Review.
-
Cost considerations in implementing a screening and surveillance strategy for Barrett's oesophagus.Best Pract Res Clin Gastroenterol. 2015 Feb;29(1):51-63. doi: 10.1016/j.bpg.2014.12.002. Epub 2014 Dec 18. Best Pract Res Clin Gastroenterol. 2015. PMID: 25743456 Review.
-
Review article: screening and surveillance of Barrett's oesophagus: what is a cost-effective framework?Aliment Pharmacol Ther. 2004 Feb;19 Suppl 1:49-53. doi: 10.1111/j.0953-0673.2004.01838.x. Aliment Pharmacol Ther. 2004. PMID: 14725579 Review.
Cited by
-
A review: targeting UBR5 domains to mediate emerging roles and mechanisms - chance or necessity?Int J Surg. 2024 Aug 1;110(8):4947-4964. doi: 10.1097/JS9.0000000000001541. Int J Surg. 2024. PMID: 38701508 Free PMC article. Review.
-
Late age at first birth is a protective factor for oesophageal cancer and gastro-oesophageal reflux: the evidence from the genetic study.Front Endocrinol (Lausanne). 2024 Jan 15;14:1329763. doi: 10.3389/fendo.2023.1329763. eCollection 2023. Front Endocrinol (Lausanne). 2024. PMID: 38288469 Free PMC article.
-
Challenge and future of cancer screening in China: Insights from esophageal cancer screening practice.Chin J Cancer Res. 2023 Dec 30;35(6):584-594. doi: 10.21147/j.issn.1000-9604.2023.06.03. Chin J Cancer Res. 2023. PMID: 38204451 Free PMC article.
-
Quantitative multiphoton imaging of cell metabolism, stromal fibers, and keratinization enables label-free discrimination of esophageal squamous cell carcinoma.Biomed Opt Express. 2023 Jul 14;14(8):4137-4155. doi: 10.1364/BOE.492109. eCollection 2023 Aug 1. Biomed Opt Express. 2023. PMID: 37799684 Free PMC article.
-
Worldwide trends in esophageal cancer survival, by sub-site, morphology, and sex: an analysis of 696,974 adults diagnosed in 60 countries during 2000-2014 (CONCORD-3).Cancer Commun (Lond). 2023 Sep;43(9):963-980. doi: 10.1002/cac2.12457. Epub 2023 Jul 24. Cancer Commun (Lond). 2023. PMID: 37488785 Free PMC article.
References
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical