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Case Reports
. 2012 Apr;32(4):1435-41.

Lymphoepithelioma-like carcinoma of the breast: a case report with a special analysis of an association with human papilloma virus

Yoshinori Nio  1 , Kazuhiko Tsuboi, Mikako Tamaoki, Masashi Tamaoki, Riruke Maruyama
Affiliations
  • PMID: 22493382
Case Reports

Lymphoepithelioma-like carcinoma of the breast: a case report with a special analysis of an association with human papilloma virus

Yoshinori Nio et al. Anticancer Res. 2012 Apr.

Abstract

Lymphoepithelioma-like carcinoma (LELC) of the breast is a very rare tumor, and fewer than 20 cases have been reported. A recent report suggested the implication of human papilloma virus (HPV) in the pathogenesis of breast LELC. We report a case of LELC of the breast with a review of its relevance to an association with HPV. A 45-year-old female patient presented with a solid mass in the outer-upper part of her left breast, which was diagnosed as malignant (ductal carcinoma) by fine-needle aspiration cytology. The patient underwent a quadrantectomy of the breast and axillary sentinel node biopsy. Pathological examination revealed cohesive sheets or nests of malignant epithelial cells, with unclear circumscription in a background of diffuse lymphoid infiltration; the postsurgical clinical stage was pT1pN0M0, stage 1. Immunohistochemistry demonstrated that the tumor was triple negative and basal-like breast cancer. In the present case in situ hybridization demonstrated positive HPV signals in a few tumor cells; however, polymerase chain reaction study failed to detect HPV in tumor cells.

Conclusion: To the best of our knowledge, this is the second report on HPV infection associated with breast LELC.

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