Review
doi: 10.1038/ja.2012.27.
Epub 2012 Apr 18.
Thoughts and facts about antibiotics: where we are now and where we are heading
Affiliations
- PMID: 22511224
- DOI: 10.1038/ja.2012.27
Item in Clipboard
Review
Thoughts and facts about antibiotics: where we are now and where we are heading
J Antibiot (Tokyo).
2012 Aug.
Erratum in
-
Thoughts and facts about antibiotics: Where we are now and where we are heading.J Antibiot (Tokyo). 2012 Aug;65(8):441. doi: 10.1038/ja.2012.54. J Antibiot (Tokyo). 2012. PMID: 22922479 No abstract available.
Abstract
The declining trends in microbial metabolite and natural products research and the refocusing of this research area are discussed. Renewing natural products research requires inexhaustible natural resources, as well as new genetic techniques and microbial sources, including endophytic microbes. The numbers of known bioactive metabolites are summarized according to their microbiological origin, biological activities and chemical structures. Synthetic and natural product-based libraries are also compared. Importantly, the wide range of microbial metabolite bioactivities, future trends and the importance of prioritizing natural products over synthetic compounds are emphasized.
Similar articles
-
Specialized microbial metabolites: functions and origins.J Antibiot (Tokyo). 2013 Jul;66(7):361-4. doi: 10.1038/ja.2013.61. Epub 2013 Jun 12. J Antibiot (Tokyo). 2013. PMID: 23756686 Review.
-
Developing new antibacterials through natural product research.Expert Opin Drug Discov. 2013 May;8(5):479-93. doi: 10.1517/17460441.2013.779666. Epub 2013 Mar 12. Expert Opin Drug Discov. 2013. PMID: 23480029 Review.
-
New approaches for studying the chemical diversity of natural resources and the bioactivity of their constituents.Chimia (Aarau). 2012;66(5):324-9. doi: 10.2533/chimia.2012.324. Chimia (Aarau). 2012. PMID: 22867545 Review.
-
Screening strategies for discovery of antibacterial natural products.Expert Rev Anti Infect Ther. 2011 Aug;9(8):589-613. doi: 10.1586/eri.11.81. Expert Rev Anti Infect Ther. 2011. PMID: 21819327 Review.
-
Bioactive microbial metabolites.J Antibiot (Tokyo). 2005 Jan;58(1):1-26. doi: 10.1038/ja.2005.1. J Antibiot (Tokyo). 2005. PMID: 15813176 Review.
Cited by
-
Plant antibacterials: The challenges and opportunities.Heliyon. 2024 May 11;10(10):e31145. doi: 10.1016/j.heliyon.2024.e31145. eCollection 2024 May 30. Heliyon. 2024. PMID: 38803958 Free PMC article. Review.
-
Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends.RSC Adv. 2024 Apr 25;14(19):13535-13564. doi: 10.1039/d4ra00631c. eCollection 2024 Apr 22. RSC Adv. 2024. PMID: 38665493 Free PMC article. Review.
-
Two strategies to improve the supply of PKS extender units for ansamitocin P-3 biosynthesis by CRISPR-Cas9.Bioresour Bioprocess. 2022 Aug 29;9(1):90. doi: 10.1186/s40643-022-00583-7. Bioresour Bioprocess. 2022. PMID: 38647752 Free PMC article.
-
Binding Mode-Based Physicochemical Screening Method Using d-Ala-d-Ala Silica Gel and Chemical Modification Approach to Facilitate Discovery of New Macrolactams, Banglactams A and B, from Nonomuraea bangladeshensis K18-0086.ACS Omega. 2024 Apr 5;9(15):17415-17422. doi: 10.1021/acsomega.4c00145. eCollection 2024 Apr 16. ACS Omega. 2024. PMID: 38645345 Free PMC article.
-
Endophytic Aspergillii and Penicillii from medicinal plants: a focus on antimicrobial and multidrug resistant pathogens inhibitory activity.BioTechnologia (Pozn). 2024 Mar 29;105(1):83-95. doi: 10.5114/bta.2024.135644. eCollection 2024. BioTechnologia (Pozn). 2024. PMID: 38633888 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
