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. 2009 Jul;1(2):26-32.

Influenza virus neuraminidase: structure and function

Y A Shtyrya  1 , L V Mochalova, N V Bovin
Affiliations

Influenza virus neuraminidase: structure and function

Y A Shtyrya et al. Acta Naturae. 2009 Jul.

Abstract

The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals.

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Figures

Fig. 1.
Fig. 1.
Active site of influenza virus A neuraminidase (N2 subtype) in complex with Neu5Ac2en (2-deoxy-2,3-didehydro-N-acetylneuraminic acid). Neu5Ac2en is presented in black, functional a.a. of the active site – red
Scheme 1
Scheme 1
Mechanism of substrate desialylation by influenza virus neuraminidase (according to [7], [15], and [16].)
Fig. 2.
Fig. 2.
Structure of а) Neu5Ac2en, b) Zanamivir, c) Oseltamivir, d) BCX-1812 (preamivir), where R=NHAc
Fig. 3.
Fig. 3.
Structure of MU-Neu5Ac (а) and NA-Star (b)
See this image and copyright information in PMC

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