Mapping mutations in prostate cancer exomes
- PMID: 22842706
- PMCID: PMC3720115
- DOI: 10.1038/aja.2012.75
Mapping mutations in prostate cancer exomes
Abstract
Comprehensive identification of driver mutations in prostate cancer can serve to enhance our understanding of the disease and expand the use of available treatment options. Two recent and complementary studies from Barbieri et al.1 and Grasso et al.2 have reported the results of exome sequencing analysis in large cohorts of primary, treatment-naïve and lethal castration-resistant prostate cancer (CRPC) cases, respectively. Together, these analyses revealed a number of novel genetic mutations representing uncharacterized drivers as well as combinations of mutations that may define important prostate cancer subtypes.
Comment on
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Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.Nat Genet. 2012 May 20;44(6):685-9. doi: 10.1038/ng.2279. Nat Genet. 2012. PMID: 22610119 Free PMC article.
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The mutational landscape of lethal castration-resistant prostate cancer.Nature. 2012 Jul 12;487(7406):239-43. doi: 10.1038/nature11125. Nature. 2012. PMID: 22722839 Free PMC article.
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