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Review
. 2012 May;22(4):98-105.
doi: 10.1016/j.tcm.2012.07.003. Epub 2012 Aug 29.

PGC-1 proteins and heart failure

Christian Riehle  1 , E Dale Abel
Affiliations
Review

PGC-1 proteins and heart failure

Christian Riehle et al. Trends Cardiovasc Med. 2012 May.

Abstract

The transcriptional coactivators PGC-1α and PGC-1β are master regulators of oxidative phosphorylation and fatty acid oxidation gene expression. Pressure overload hypertrophy and heart failure are associated with repressed PGC-1α and PGC-1β gene expression. Maintaining expression of PGC-1α and -β preserves contractile function in response to a pathological increase in workload. Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure.

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Conflict of interest statement

Conflict of Interest

None.

Figures

Figure 1
Figure 1
Multiple stimuli increase (indicated by +) or decrease (indicated by −) PGC-1α expression. PGC-1α coactivates PPAR and ERR transcription factors and thereby regulates the expression of genes involved in mitochondrial fatty acid import and oxidation. In addition, PGC-1α regulates the expression of nuclear encoded oxidative phosphorylation (OXPHOS) subunits via coactivation of ERRs, NRF-1 and NRF-2. NRF-1 and NRF-2 also bind to the promoter of the mitochondrial transcription factor A (TFAm) and coordinates the transcription of the nuclear and mitochondrial genome.
Figure 2
Figure 2
Key features of myocardial energy metabolism in response to physiological and pathological hypertrophy.
See this image and copyright information in PMC

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