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. 2012 Nov 19;18(47):14918-22.
doi: 10.1002/chem.201202575. Epub 2012 Oct 30.

Cobalt(II)-catalyzed 1,4-addition of organoboronic acids to activated alkenes: an application to highly cis-stereoselective synthesis of aminoindane carboxylic acid derivatives

Min-Hsien Chen  1 , Subramaniyan Mannathan, Pao-Shun Lin, Chien-Hong Cheng
Affiliations

Cobalt(II)-catalyzed 1,4-addition of organoboronic acids to activated alkenes: an application to highly cis-stereoselective synthesis of aminoindane carboxylic acid derivatives

Min-Hsien Chen et al. Chemistry. .

Abstract

It all adds up: The 1,4-addition of organoboronic acids to activated alkenes catalyzed by [Co(dppe)Cl(2)] is described. A [3+2]-annulation reaction of ortho-iminoarylboronic acids with acrylates to give various aminoindane carboxylic acid derivatives with cis-stereoselectivity is also demonstrated (see scheme; dppe = 1,2-bis(diphenylphosphino)ethane).

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