Prognostic factors in critically ill patients with hematologic malignancies admitted to the intensive care unit
- PMID: 23217573
- DOI: 10.1016/j.jcrc.2012.07.014
Prognostic factors in critically ill patients with hematologic malignancies admitted to the intensive care unit
Abstract
Objective: Despite an improvement in the prognosis of patients with hematologic malignancies, the mortality of such patients transferred to the intensive care unit (ICU) is high. This study determined the predictors of mortality in a cohort of critically ill patients with hematologic malignancies admitted to the ICU.
Methods: We studied 227 critically ill patients with hematologic malignancies who were admitted to the ICU between April 2009 and December 2011. A cohort of consecutive patients with hematologic malignancies was reviewed retrospectively to identify clinically useful prognostic factors.
Results: The ICU mortality rate was 84.1%, and the in-hospital mortality rate was 89.9%. The ICU mortality was significantly higher in patients with acute leukemia than in those with other malignancies. A significant difference between survivors and nonsurvivors was found in neutropenia and its recovery during the ICU stay, presence of cardiac dysfunction, the need for an invasive mechanical ventilator, use of inotropic/vasopressor agents, platelet count, aspartate transaminase level, pH, and Acute Physiology And Chronic Health Evaluation II score. In the multivariate analysis, acute leukemia, need for invasive mechanical ventilator, use of inotropic/vasopressor agents, and Acute Physiology And Chronic Health Evaluation II scores were independently associated with a worse outcome in patients with hematologic malignancies admitted to the ICU.
Conclusion: Higher mortality in patients with hematologic malignancies admitted to the ICU is associated with more severe illness, as reflected by higher organ failure scores or respiratory or hemodynamic instability. Mortality is higher in patients with acute leukemia as compared with other hematologic malignancies.
Crown Copyright © 2012. Published by Elsevier Inc. All rights reserved.
Similar articles
-
Managing critically Ill hematology patients: Time to think differently.Blood Rev. 2015 Nov;29(6):359-67. doi: 10.1016/j.blre.2015.04.002. Epub 2015 Apr 26. Blood Rev. 2015. PMID: 25998991 Review.
-
The effect of positive balance on the outcomes of critically ill noncardiac postsurgical patients: a retrospective cohort study.J Crit Care. 2014 Feb;29(1):43-8. doi: 10.1016/j.jcrc.2013.08.009. Epub 2013 Oct 17. J Crit Care. 2014. PMID: 24140168
-
Outcome of critically ill patients with hematological malignancies.Ann Hematol. 2013 May;92(5):699-705. doi: 10.1007/s00277-013-1675-7. Epub 2013 Jan 18. Ann Hematol. 2013. PMID: 23328791
-
Outcomes and prognostic factors in patients with haematological malignancy admitted to a specialist cancer intensive care unit: a 5 yr study.Br J Anaesth. 2012 Mar;108(3):452-9. doi: 10.1093/bja/aer449. Epub 2012 Jan 31. Br J Anaesth. 2012. PMID: 22298243 Review.
-
Prognostic factors and utility of scoring systems in patients with hematological malignancies admitted to the intensive care unit and required a mechanical ventilator.Hawaii Med J. 2008 Oct;67(10):264-9. Hawaii Med J. 2008. PMID: 19097551
Cited by
-
Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit.Exp Ther Med. 2024 Feb 27;27(4):168. doi: 10.3892/etm.2024.12457. eCollection 2024 Apr. Exp Ther Med. 2024. PMID: 38476903 Free PMC article.
-
Deep Learning-Based Early Warning Score for Predicting Clinical Deterioration in General Ward Cancer Patients.Cancers (Basel). 2023 Oct 26;15(21):5145. doi: 10.3390/cancers15215145. Cancers (Basel). 2023. PMID: 37958319 Free PMC article.
-
Advances in the use of ECMO in oncology patient.Cancer Med. 2023 Aug;12(15):16243-16253. doi: 10.1002/cam4.6288. Epub 2023 Jul 17. Cancer Med. 2023. PMID: 37458111 Free PMC article. Review.
-
Risk factors for ICU mortality in patients with hematological malignancies: a singlecenter, retrospective cohort study from Turkey.Turk J Med Sci. 2023 Feb;53(1):340-351. doi: 10.55730/1300-0144.5590. Epub 2023 Feb 22. Turk J Med Sci. 2023. PMID: 36945922 Free PMC article.
-
Risk Factors for Mortality and Outcomes in Hematological Malignancy Patients with Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections.Infect Drug Resist. 2022 Aug 4;15:4241-4251. doi: 10.2147/IDR.S374904. eCollection 2022. Infect Drug Resist. 2022. PMID: 35959146 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous