Th22 and related cytokines in inflammatory and autoimmune diseases
- PMID: 23256771
- DOI: 10.1517/14728222.2013.736497
Th22 and related cytokines in inflammatory and autoimmune diseases
Abstract
Introduction: Th22 and related cytokines regulate various processes and have been linked to diverse effects. The levels of Th22 and cytokine IL-22 are increased in several disorders and positively related to some autoimmune diseases. Preclinical studies have suggested that the inhibition or stimulation of IL-22 is an attractive approach to reverse the immune disorders. Simultaneously, considering many patients with refractory autoimmune diseases respond poorly to the therapies which are highly toxic, more effective therapies are to be examined.
Areas covered: The role of Th22 cells and related cytokines and therapeutic strategies targeting them in many illnesses, especially inflammatory and autoimmune diseases.
Expert opinion: Th22 cells and related cytokine IL-22 regulate multiple biological functions and play an important role in a number of inflammatory and autoimmune diseases. They have unique and attractive advantages for targeting. Targeting IL-22 has already been trialed in many mice experiments, showing better efficacy and fewer side effects compared with classical drugs. Targeting IL-22 or Th22 might provide pathogenetic treatment. However, Th22 subset is a recently identified Th subset and its associated research is extremely limited. Therefore, there are still many unanswered questions and further researches are warranted.
Comment in
-
Comment and reply on: emerging role of Th22 and IL-22 in multiple sclerosis, an autoimmune disease in the central nervous system.Expert Opin Ther Targets. 2013 Nov;17(11):1381-2. doi: 10.1517/14728222.2013.844461. Epub 2013 Oct 3. Expert Opin Ther Targets. 2013. PMID: 24090224 No abstract available.
-
Authors' response.Expert Opin Ther Targets. 2013 Nov;17(11):1382. Expert Opin Ther Targets. 2013. PMID: 24278982 No abstract available.
Similar articles
-
Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases.Front Immunol. 2021 Jul 6;12:688066. doi: 10.3389/fimmu.2021.688066. eCollection 2021. Front Immunol. 2021. PMID: 34295334 Free PMC article. Review.
-
Features and roles of T helper 22 cells in immunological diseases and malignancies.Scand J Immunol. 2021 May;93(5):e13030. doi: 10.1111/sji.13030. Epub 2021 Feb 22. Scand J Immunol. 2021. PMID: 33576072 Review.
-
Th22 Cells Contribution in Immunopathogenesis of Rheumatic Diseases.Iran J Allergy Asthma Immunol. 2015 Jun;14(3):246-54. Iran J Allergy Asthma Immunol. 2015. PMID: 26546892 Review.
-
The biology and functions of Th22 cells.Adv Exp Med Biol. 2014;841:209-30. doi: 10.1007/978-94-017-9487-9_8. Adv Exp Med Biol. 2014. PMID: 25261209 Review.
-
Targeting the Notch signaling pathway in autoimmune diseases.Expert Opin Ther Targets. 2010 May;14(5):553-65. doi: 10.1517/14728221003752750. Expert Opin Ther Targets. 2010. PMID: 20334488 Review.
Cited by
-
Dual Functions of T Lymphocytes in Breast Carcinoma: From Immune Protection to Orchestrating Tumor Progression and Metastasis.Cancers (Basel). 2023 Sep 28;15(19):4771. doi: 10.3390/cancers15194771. Cancers (Basel). 2023. PMID: 37835465 Free PMC article. Review.
-
Recent Progress in Multiple Sclerosis Treatment Using Immune Cells as Targets.Pharmaceutics. 2023 Feb 22;15(3):728. doi: 10.3390/pharmaceutics15030728. Pharmaceutics. 2023. PMID: 36986586 Free PMC article. Review.
-
The Role of T Helper 22 Cells in Dermatological Disorders.Front Immunol. 2022 Jul 14;13:911546. doi: 10.3389/fimmu.2022.911546. eCollection 2022. Front Immunol. 2022. PMID: 35911703 Free PMC article. Review.
-
Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus.J Dent (Shiraz). 2020 Dec;21(4):330-334. doi: 10.30476/DENTJODS.2020.84667.1096. J Dent (Shiraz). 2020. PMID: 33344684 Free PMC article.
-
MiR-31 promotes Th22 differentiation through targeting Bach2 in coronary heart disease.Biosci Rep. 2019 Sep 20;39(9):BSR20190986. doi: 10.1042/BSR20190986. Print 2019 Sep 30. Biosci Rep. 2019. PMID: 31501353 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical