Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
- PMID: 23453003
- PMCID: PMC3587983
- DOI: 10.1016/j.reprotox.2012.11.011
Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
Abstract
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats were transiently exposed during the fetal gonadal development period. The direct exposure F1 generation had an increased incidence of kidney abnormalities in both females and males, prostate and pubertal abnormalities in males, and primordial follicle loss and polycystic ovarian disease in females. The first transgenerational generation is the F3 generation, and the jet fuel lineage had an increased incidence of primordial follicle loss and polycystic ovarian disease in females, and obesity in both females and males. Analysis of the jet fuel lineage F3 generation sperm epigenome identified 33 differential DNA methylation regions, termed epimutations. Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures.
Copyright © 2012 Elsevier Inc. All rights reserved.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3587983/bin/nihms426647f1.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3587983/bin/nihms426647f2.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3587983/bin/nihms426647f3.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3587983/bin/nihms426647f4.gif)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3587983/bin/nihms426647f5.gif)
![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3587983/bin/nihms426647f6.gif)
![Figure 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3587983/bin/nihms426647f7.gif)
![Figure 8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3587983/bin/nihms426647f8.gif)
Similar articles
-
Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult-onset disease through the female germline.PLoS One. 2014 Jul 24;9(7):e102091. doi: 10.1371/journal.pone.0102091. eCollection 2014. PLoS One. 2014. PMID: 25057798 Free PMC article.
-
Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations.PLoS One. 2013;8(1):e55387. doi: 10.1371/journal.pone.0055387. Epub 2013 Jan 24. PLoS One. 2013. PMID: 23359474 Free PMC article.
-
Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.PLoS One. 2012;7(9):e46249. doi: 10.1371/journal.pone.0046249. Epub 2012 Sep 26. PLoS One. 2012. PMID: 23049995 Free PMC article.
-
Environmentally induced epigenetic transgenerational inheritance of male infertility.Curr Opin Genet Dev. 2014 Jun;26:79-88. doi: 10.1016/j.gde.2014.06.005. Epub 2014 Aug 11. Curr Opin Genet Dev. 2014. PMID: 25104619 Free PMC article. Review.
-
Transgenerational Epigenetics: A Window into Paternal Health Influences on Offspring.Urol Clin North Am. 2020 May;47(2):219-225. doi: 10.1016/j.ucl.2019.12.010. Epub 2020 Mar 9. Urol Clin North Am. 2020. PMID: 32272994 Review.
Cited by
-
Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution.Epigenetics. 2024 Dec;19(1):2380929. doi: 10.1080/15592294.2024.2380929. Epub 2024 Aug 5. Epigenetics. 2024. PMID: 39104183 Free PMC article. Review.
-
Childhood obesity from the genes to the epigenome.Front Endocrinol (Lausanne). 2024 Jul 9;15:1393250. doi: 10.3389/fendo.2024.1393250. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39045266 Free PMC article. Review.
-
Multiple generation distinct toxicant exposures induce epigenetic transgenerational inheritance of enhanced pathology and obesity.Environ Epigenet. 2023 Dec 7;9(1):dvad006. doi: 10.1093/eep/dvad006. eCollection 2023. Environ Epigenet. 2023. PMID: 38162685 Free PMC article.
-
Transgenerational sperm DMRs escape DNA methylation erasure during embryonic development and epigenetic inheritance.Environ Epigenet. 2023 Jun 3;9(1):dvad003. doi: 10.1093/eep/dvad003. eCollection 2023. Environ Epigenet. 2023. PMID: 37346491 Free PMC article.
-
Paternal Combined Botanicals Contribute to the Prevention of Estrogen Receptor-Negative Mammary Cancer in Transgenic Mice.J Nutr. 2023 Jul;153(7):1959-1973. doi: 10.1016/j.tjnut.2023.05.001. Epub 2023 May 3. J Nutr. 2023. PMID: 37146973 Free PMC article. Clinical Trial.
References
-
- Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 2005;308:1466–1469. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous