Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jul;113(3):353-8.
doi: 10.1007/s11060-013-1131-5. Epub 2013 Apr 24.

BRAF alterations in pediatric low grade gliomas and mixed neuronal-glial tumors

Efthymios Dimitriadis  1 , George A Alexiou, Panagiota Tsotsou, Efthymia Simeonidi, Kalliopi Stefanaki, Amalia Patereli, Neofytos Prodromou, Nikolaos Pandis
Affiliations

BRAF alterations in pediatric low grade gliomas and mixed neuronal-glial tumors

Efthymios Dimitriadis et al. J Neurooncol. 2013 Jul.

Abstract

Low grade astrocytomas are the most common brain tumor in children. Recent studies have identified alterations in the BRAF serine/threonine kinase gene that result in mitogen activated protein kinase pathway activation. Herewith, we investigated the genetic changes of BRAF in pediatric low grade gliomas and their relation to pathological findings and Ki-67 proliferation index. The results showed gene fusions between KIAA1549 and BRAF in 66.7 % of tumors. The majority involved the KIAA1549-BRAF exon 16-exon 9 variant. Fusion junction between KIAA1549 exon 15 and BRAF exon 9 was found in five tumors, in which the myxoid component was the predominant. This has not been previously reported. No significant correlation was found between specific KIAA1549 and BRAF fusion junctions and Ki-67 index. All of the samples included in this study were tested for the presence of the BRAF(V600E) mutation, and no positive sample was found.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cancer Res. 2008 Nov 1;68(21):8673-7 - PubMed
    1. Br J Cancer. 2009 Aug 18;101(4):722-33 - PubMed
    1. Cent Eur Neurosurg. 2011 Feb;72(1):1-4 - PubMed
    1. J Pathol. 2009 Jun;218(2):172-81 - PubMed
    1. Acta Neuropathol. 2011 Jun;121(6):763-74 - PubMed

MeSH terms

Substances

LinkOut - more resources

-