Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues

doi:10.1016/j.jsps.2010.05.004

. 2010 Jul;18(3):123-8.

doi: 10.1016/j.jsps.2010.05.004. Epub 2010 May 31.

Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues

Ghada S Hassan¹, Ali A El-Emam, Laila M Gad, Alaa Eldin M Barghash

Affiliations

PMID: 23964171
PMCID: PMC3730972
DOI: 10.1016/j.jsps.2010.05.004

Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues

Ghada S Hassan et al. Saudi Pharm J. 2010 Jul.

. 2010 Jul;18(3):123-8.

doi: 10.1016/j.jsps.2010.05.004. Epub 2010 May 31.

Authors

Ghada S Hassan¹, Ali A El-Emam, Laila M Gad, Alaa Eldin M Barghash

Affiliation

¹ Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

PMID: 23964171
PMCID: PMC3730972
DOI: 10.1016/j.jsps.2010.05.004

Abstract

A new series of 1-adamantyl derivatives was designed, synthesized and evaluated for their antimicrobial and antiviral activities. Representative derivatives of the newly synthesized compounds were tested. Ampicillin, clotimazole and the antiviral antibiotic aphidicolin were used as positive controls. Compound 18 proved to be the most active member of this series as antimicrobial against Staphylococcus aureus and Candida albicans and as antiviral with IC50 value of 0.21 mg/ml and CD50 value of 0.02 mg/ml while compound 19 proved to be the most active member of this series as antiviral with IC50 value of 0.21 mg/ml and CD50 value of 0.01 mg/ml.

Keywords: 1-Adamantyl; Antimicrobial testing; Antiviral screening; Synthesis.

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References

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[1] Abadi A., Abdel Haleem A., Hassan G. Synthesis of novel 1,3,4-trisubstituted pyrazole derivatives and their evaluation as antitumor and antiangiogenic agents. Chem. Pharm. Bull. 2003;51:838–844. - PubMed

[2] Abadi A., Abdel Haleem A., Hassan G. Synthesis of novel 1,3,4-trisubstituted pyrazole derivatives and their evaluation as antitumor and antiangiogenic agents. Chem. Pharm. Bull. 2003;51:838–844. - PubMed

[3] Blain J., Linnest E., Traunat J. American Society of Microbiology; Bethesda, MS, USA: 1970. Manual of Clinical Microbiology. (pp. 300–303)

[4] Blain J., Linnest E., Traunat J. American Society of Microbiology; Bethesda, MS, USA: 1970. Manual of Clinical Microbiology. (pp. 300–303)

[5] Bormasheva K.M., Nechaeva O.N., Moiseev I.K. Reactions of adamantyl-substituted keto esters with hydrazine and phenylhydrazine. Russ. J. Org. Chem. 2008;44(12):1760–1764.

[6] Bormasheva K.M., Nechaeva O.N., Moiseev I.K. Reactions of adamantyl-substituted keto esters with hydrazine and phenylhydrazine. Russ. J. Org. Chem. 2008;44(12):1760–1764.

[7] Chimirri A., Grasso S., Monforte A.M., Monforte P., Zappala M., Carrotti A. Synthesis and in vitro anti HIV activity of novel Δ2-1,2,4-oxadiazoline derivatives. Farmaco. 1994;49:509–511. - PubMed

[8] Chimirri A., Grasso S., Monforte A.M., Monforte P., Zappala M., Carrotti A. Synthesis and in vitro anti HIV activity of novel Δ2-1,2,4-oxadiazoline derivatives. Farmaco. 1994;49:509–511. - PubMed

[9] El-Emam A.A., Al-Deeb O.A., Al-Omar M., Lehmann J. Synthesis, antimicrobial and anti-HIV-1 activity of certain 5-(1-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminoethyl-1,3,4-oxadiazoline-2-thiones. Bioorg. Med. Chem. 2004;12:5107–5113. - PubMed

[10] El-Emam A.A., Al-Deeb O.A., Al-Omar M., Lehmann J. Synthesis, antimicrobial and anti-HIV-1 activity of certain 5-(1-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminoethyl-1,3,4-oxadiazoline-2-thiones. Bioorg. Med. Chem. 2004;12:5107–5113. - PubMed

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Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues

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Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues

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