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Review
. 2013;207(2):109-21.
doi: 10.1051/jbio/2013011. Epub 2013 Oct 10.

[Retinitis pigmentosa: eye sight restoration by optogenetic therapy]

[Article in French]
Botond Roska  1 , Volker Busskamp, José Alain Sahel, Serge Picaud
Affiliations
Review

[Retinitis pigmentosa: eye sight restoration by optogenetic therapy]

[Article in French]
Botond Roska et al. Biol Aujourdhui. 2013.

Abstract

Retinitis pigmentosa (RP) is a hereditary retinal disease leading to blindness, which affects two million people worldwide. Restoring vision in these blind patients was proposed by gene delivery of microbial light-activated ionic channels or pumps "optogenetic proteins" to transform surviving cells into artificial photoreceptors. This therapeutic strategy was validated in blind animal models of RP by recording at the level of the retina and cortex and by behavioural tests. The translational potentials of these optogenetic approaches have been evaluated using in vitro studies on post-mortem human retinal tissues. Here, we review these recent results and discuss the potential clinical applications of the optogenetic therapy for RP patients.

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