Cross-talk between site-specific transcription factors and DNA methylation states
- PMID: 24151070
- PMCID: PMC3843044
- DOI: 10.1074/jbc.R113.512517
Cross-talk between site-specific transcription factors and DNA methylation states
Abstract
DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. Because DNA methylation is reversible, there is much interest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.
Keywords: DNA Methylation; DNA-binding Protein; Epigenetics; Gene Regulation; Transcription Factors.
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