[Bacterial biofilm as a cause of urinary tract infection--pathogens, methods of prevention and eradication]
- PMID: 24184954
- DOI: 10.5604/17322693.1073567
[Bacterial biofilm as a cause of urinary tract infection--pathogens, methods of prevention and eradication]
Abstract
Urinary tract infections (UTI) are one of the common chronic and recurrent bacterial infections. Uropathogens which are able to form biofilm constitute a major etiological factor in UTI, especially among elder patients who are subject to long-term catheterization. It is caused by the capacity of the microorganisms for efficient and permanent colonization of tissues and also adhesion to diverse polymers used for urological catheter production such as propylene, polystyrene, silicone, polyvinyl chloride or silicone coated latex. Antibiotic therapy is the most common treatment for UTI. Fluoroquinolones, nitrofurans, beta-lactams, aminoglycosides, trimethoprim and sulfonamides are used predominantly. However, the biofilm due to its complex structure constitutes an effective barrier to the antibiotics used in the treatment of urinary tract infections. In addition, the growing number of multidrug resistant strains limits the usage of many of the currently available chemotherapeutic agents. Therefore, it seems important to search for new methods of treatment such as coating of catheters with non-pathogenic E. coli strains, the design of vaccines against fimbrial adhesive proteins of the bacterial cells or the use of bacteriophages.
Similar articles
-
Restriction of in vivo infection by antifouling coating on urinary catheter with controllable and sustained silver release: a proof of concept study.BMC Infect Dis. 2018 Aug 6;18(1):370. doi: 10.1186/s12879-018-3296-1. BMC Infect Dis. 2018. PMID: 30081836 Free PMC article.
-
Chronic urinary tract infections in patients with spinal cord lesions - biofilm infection with need for long-term antibiotic treatment.APMIS. 2017 Apr;125(4):385-391. doi: 10.1111/apm.12685. APMIS. 2017. PMID: 28407430 Review.
-
Bacterial characteristics of importance for recurrent urinary tract infections caused by Escherichia coli.Dan Med Bull. 2011 Apr;58(4):B4187. Dan Med Bull. 2011. PMID: 21466767 Review.
-
Antibiofilm effect of trans-cinnamaldehyde on uropathogenic Escherichia coli.J Urol. 2010 Jul;184(1):358-63. doi: 10.1016/j.juro.2010.03.006. Epub 2010 May 20. J Urol. 2010. PMID: 20488489
-
Specific selection for virulent urinary tract infectious Escherichia coli strains during catheter-associated biofilm formation.FEMS Immunol Med Microbiol. 2007 Oct;51(1):212-9. doi: 10.1111/j.1574-695X.2007.00296.x. Epub 2007 Jul 23. FEMS Immunol Med Microbiol. 2007. PMID: 17645737
Cited by
-
Insulin Regulation of Escherichia coli Abiotic Biofilm Formation: Effect of Nutrients and Growth Conditions.Antibiotics (Basel). 2021 Nov 5;10(11):1349. doi: 10.3390/antibiotics10111349. Antibiotics (Basel). 2021. PMID: 34827287 Free PMC article.
-
Effects of Selected Egyptian Honeys on the Cellular Ultrastructure and the Gene Expression Profile of Escherichia coli.PLoS One. 2016 Mar 8;11(3):e0150984. doi: 10.1371/journal.pone.0150984. eCollection 2016. PLoS One. 2016. PMID: 26954570 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical