Synthesis and SAR study of a novel series of dopamine receptor agonists
- PMID: 24296012
- DOI: 10.1016/j.bmc.2013.11.012
Synthesis and SAR study of a novel series of dopamine receptor agonists
Abstract
The synthesis of a novel series of dopamine receptor agonists are described as well as their in vitro potency and efficacy on dopamine D₁ and D₂ receptors. This series was designed from pergolide and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinolin-6-ol (PHBQ) and resulted in the synthesis of (2R,4aR,10aR)-2-methylsulfanylmethyl-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-9-ol (compound 27), which has a D₁ and D₂ receptor profile similar to that of the most recently approved drug for Parkinson's disease, rotigotine.
Keywords: Dopamine receptor agonist; Parkinson’s disease; Rotigotine.
Copyright © 2013 Elsevier Ltd. All rights reserved.
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