Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention

doi:10.1158/1055-9965.EPI-13-1057

Review

. 2014 May;23(5):700-13.

doi: 10.1158/1055-9965.EPI-13-1057. Epub 2014 Mar 11.

Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention

Parisa Karimi¹, Farhad Islami, Sharmila Anandasabapathy, Neal D Freedman, Farin Kamangar

Affiliations

Affiliation

¹ Authors' Affiliations: Johns Hopkins Bloomberg School of Public Health; Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Institute for Transitional Epidemiology, Mount Sinai School of Medicine; Division of Gastroenterology, Department of Medicine, Mount Sinai Medical Center, New York, New York; and Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 24618998
PMCID: PMC4019373
DOI: 10.1158/1055-9965.EPI-13-1057

Review

Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention

Parisa Karimi et al. Cancer Epidemiol Biomarkers Prev. 2014 May.

. 2014 May;23(5):700-13.

doi: 10.1158/1055-9965.EPI-13-1057. Epub 2014 Mar 11.

Authors

Parisa Karimi¹, Farhad Islami, Sharmila Anandasabapathy, Neal D Freedman, Farin Kamangar

Affiliation

¹ Authors' Affiliations: Johns Hopkins Bloomberg School of Public Health; Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Institute for Transitional Epidemiology, Mount Sinai School of Medicine; Division of Gastroenterology, Department of Medicine, Mount Sinai Medical Center, New York, New York; and Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 24618998
PMCID: PMC4019373
DOI: 10.1158/1055-9965.EPI-13-1057

Abstract

Less than a century ago, gastric cancer was the most common cancer in the United States and perhaps throughout the world. Despite its worldwide decline in incidence over the past century, gastric cancer remains a major killer across the globe. This article reviews the epidemiology, screening, and prevention of gastric cancer. We first discuss the descriptive epidemiology of gastric cancer, including its incidence, survival, mortality, and trends over time. Next, we characterize the risk factors for gastric cancer, both environmental and genetic. Serologic markers and histological precursor lesions of gastric cancer and early detection of gastric cancer using these markers are reviewed. Finally, we discuss prevention strategies and provide suggestions for further research.

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References

1. Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132:1133–45. - PubMed
1. Lauren P. The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. An Attempt at a Histo-Clinical Classification. Acta Pathol Microbiol Scand. 1965;64:31–49. - PubMed
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1. Jemal A, Center MM, DeSantis C, Ward EM. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 2010;19:1893–907. - PubMed

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[1] Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132:1133–45. - PubMed

[2] Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132:1133–45. - PubMed

[3] Lauren P. The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. An Attempt at a Histo-Clinical Classification. Acta Pathol Microbiol Scand. 1965;64:31–49. - PubMed

[4] Lauren P. The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. An Attempt at a Histo-Clinical Classification. Acta Pathol Microbiol Scand. 1965;64:31–49. - PubMed

[5] Henson DE, Dittus C, Younes M, Nguyen H, Albores-Saavedra J. Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States, 1973-2000: increase in the signet ring cell type. Arch Pathol Lab Med. 2004;128:765–70. - PubMed

[6] Henson DE, Dittus C, Younes M, Nguyen H, Albores-Saavedra J. Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States, 1973-2000: increase in the signet ring cell type. Arch Pathol Lab Med. 2004;128:765–70. - PubMed

[7] Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917. - PubMed

[8] Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917. - PubMed

[9] Jemal A, Center MM, DeSantis C, Ward EM. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 2010;19:1893–907. - PubMed

[10] Jemal A, Center MM, DeSantis C, Ward EM. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 2010;19:1893–907. - PubMed

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Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention

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Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention

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