Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia
- PMID: 24650500
- PMCID: PMC4024332
- DOI: 10.1016/j.conb.2013.11.003
Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia
Abstract
Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein parvalbumin (PV). Recent studies have revealed new facets of the development of PV neurons in primate neocortex and of the nature of their molecular alterations in individuals with schizophrenia. Other recent studies in model systems provide insight into how these alterations may arise in the course of cortical circuitry development.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Figures
Similar articles
-
GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia.Neural Plast. 2011;2011:723184. doi: 10.1155/2011/723184. Epub 2011 Sep 5. Neural Plast. 2011. PMID: 21904685 Free PMC article. Review.
-
NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia.Schizophr Bull. 2012 Sep;38(5):950-7. doi: 10.1093/schbul/sbs010. Epub 2012 Feb 21. Schizophr Bull. 2012. PMID: 22355184 Free PMC article. Review.
-
Alterations of cortical GABA neurons and network oscillations in schizophrenia.Curr Psychiatry Rep. 2010 Aug;12(4):335-44. doi: 10.1007/s11920-010-0124-8. Curr Psychiatry Rep. 2010. PMID: 20556669 Free PMC article. Review.
-
Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia.Biol Psychiatry. 2015 Jun 15;77(12):1031-40. doi: 10.1016/j.biopsych.2015.03.010. Epub 2015 Mar 17. Biol Psychiatry. 2015. PMID: 25863358 Free PMC article. Review.
-
Prefrontal cortical circuits in schizophrenia.Curr Top Behav Neurosci. 2010;4:485-508. doi: 10.1007/7854_2010_44. Curr Top Behav Neurosci. 2010. PMID: 21312410 Review.
Cited by
-
Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons.BMC Neurosci. 2024 Mar 4;25(1):12. doi: 10.1186/s12868-024-00858-z. BMC Neurosci. 2024. PMID: 38438989 Free PMC article.
-
Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely-moving macaques.bioRxiv [Preprint]. 2024 May 22:2023.12.06.570369. doi: 10.1101/2023.12.06.570369. bioRxiv. 2024. Update in: Cell Rep. 2024 Aug 27;43(8):114519. doi: 10.1016/j.celrep.2024.114519. PMID: 38106053 Free PMC article. Updated. Preprint.
-
Increased Central Auditory Gain and Decreased Parvalbumin-Positive Cortical Interneuron Density in the Df1/+ Mouse Model of Schizophrenia Correlate With Hearing Impairment.Biol Psychiatry Glob Open Sci. 2022 Mar 16;3(3):386-397. doi: 10.1016/j.bpsgos.2022.03.007. eCollection 2023 Jul. Biol Psychiatry Glob Open Sci. 2022. PMID: 37519460 Free PMC article.
-
DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models.PLoS Biol. 2023 Apr 20;21(4):e3002078. doi: 10.1371/journal.pbio.3002078. eCollection 2023 Apr. PLoS Biol. 2023. PMID: 37079499 Free PMC article.
-
Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period.Elife. 2022 Dec 28;11:e80324. doi: 10.7554/eLife.80324. Elife. 2022. PMID: 36576777 Free PMC article.
References
-
- Guidotti A, Auta J, Davis JM, Gerevini VD, Dwivedi Y, Grayson DR, Impagnatiello F, Pandey G, Pesold C, Sharma R, et al. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder. Arch Gen Psychiatry. 2000;57:1061–1069. - PubMed
-
-
Rowland LM, Kontson K, West J, Edden RA, Zhu H, Wijtenburg SA, Holcomb HH, Barker PB. In vivo measurements of glutamate, GABA, and NAAG in schizophrenia. Schizophr Bull. 2013;39:1096–1104. This study represents an important addition to the literature on in vivo measures of cortical GABA levels in subjects with schizophrenia and helps explain why current findings are discrepant.
-
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical