Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential
- PMID: 24658275
- PMCID: PMC4158750
- DOI: 10.1038/nrc3701
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential
Abstract
The glucose-regulated proteins (GRPs) are stress-inducible chaperones that mostly reside in the endoplasmic reticulum or the mitochondria. Recent advances show that the GRPs have functions that are distinct from those of the related heat shock proteins, and they can be actively translocated to other cellular locations and assume novel functions that control signalling, proliferation, invasion, apoptosis, inflammation and immunity. Mouse models further identified their specific roles in development, tumorigenesis, metastasis and angiogenesis. This Review describes their discovery and regulation, as well as their biological functions in cancer. Promising agents that use or target the GRPs are being developed, and their efficacy as anticancer therapeutics is also discussed.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4158750/bin/nihms621506f1.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4158750/bin/nihms621506f2.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4158750/bin/nihms621506f3.gif)
![None](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4158750/bin/nihms621506f4.gif)
Similar articles
-
The role of heat shock proteins and glucose regulated proteins in cancer.Malays J Pathol. 2016 Aug;38(2):75-82. Malays J Pathol. 2016. PMID: 27568663
-
Hsp70: anti-apoptotic and tumorigenic protein.Methods Mol Biol. 2011;787:205-30. doi: 10.1007/978-1-61779-295-3_16. Methods Mol Biol. 2011. PMID: 21898238
-
Glucose regulated proteins in cancer progression, drug resistance and immunotherapy.Cancer Biol Ther. 2006 Jul;5(7):741-4. doi: 10.4161/cbt.5.7.2970. Epub 2006 Jul 1. Cancer Biol Ther. 2006. PMID: 16861902 Review.
-
Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/peptide-binding protein 74 (PBP74) and GRP94.Biochem J. 2001 Jul 15;357(Pt 2):393-8. doi: 10.1042/0264-6021:3570393. Biochem J. 2001. PMID: 11439088 Free PMC article.
-
The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications.Crit Rev Eukaryot Gene Expr. 1994;4(1):1-18. doi: 10.1615/critreveukargeneexpr.v4.i1.10. Crit Rev Eukaryot Gene Expr. 1994. PMID: 7987045 Review.
Cited by
-
Possible role of endoplasmic reticulum stress in the pathogenesis of chronic adenoiditis and adenoid hypertrophy: A prospective, parallel-group study.Laryngoscope Investig Otolaryngol. 2024 Apr 9;9(2):e1240. doi: 10.1002/lio2.1240. eCollection 2024 Apr. Laryngoscope Investig Otolaryngol. 2024. PMID: 38596230 Free PMC article.
-
N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease.Biomolecules. 2024 Feb 27;14(3):282. doi: 10.3390/biom14030282. Biomolecules. 2024. PMID: 38540703 Free PMC article. Review.
-
Rolapitant treats lung cancer by targeting deubiquitinase OTUD3.Cell Commun Signal. 2024 Mar 27;22(1):195. doi: 10.1186/s12964-024-01519-8. Cell Commun Signal. 2024. PMID: 38539203 Free PMC article.
-
A novel mitochondria-related core gene signature to predict the prognosis and evaluate tumour microenvironment in CESC single-cell validation.J Cell Mol Med. 2024 Apr;28(8):e18265. doi: 10.1111/jcmm.18265. J Cell Mol Med. 2024. PMID: 38534098 Free PMC article.
-
Introduction of a new recombinant vaccine based on GRP78 for breast cancer immunotherapy and evaluation in a mouse model.Bioimpacts. 2024;14(2):27829. doi: 10.34172/bi.2023.27829. Epub 2023 Sep 18. Bioimpacts. 2024. PMID: 38505675 Free PMC article.
References
-
- Lee AS. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res. 2007;67:3496–3499. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources