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. 2014 May 19.
doi: 10.1111/imm.12321. Online ahead of print.

Cellular metabolism modulation in T lymphocyte immunity

Huanrong Liu  1 , Hui Yang, Xi Chen, Yun Lu, Zhengguo Zhang, Jian Wang, Ming Zhang, Lixiang Xue, Feng Xue, Guangwei Liu
Affiliations
Free article

Cellular metabolism modulation in T lymphocyte immunity

Huanrong Liu et al. Immunology. .
Free article

Abstract

T lymphocytes are a central component, and play an important role in controlling immunity and immunological diseases. Recent studies have shown that T cell metabolism is highly dynamic and has a tremendous impact on the modulation of T lymphocyte immunity. Specific metabolic pathways meet energy and biosynthetic requirements that can support specific T cell functional activities in immunity and immunological diseases. This review summarizes the recent progresses about the modulatory role of cell metabolism in T cell development, differentiation, activation and function in immunity. These might provide new opportunities to modulate the immune responses and treat clinical immunological diseases. This article is protected by copyright. All rights reserved.

Keywords: mTOR; Amino acid; Glycosis; HIF1α; Metabolism; T cell development; TH1 cells; Treg; c-myc; fatty acid.

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