Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source
- PMID: 25011108
- PMCID: PMC4096718
- DOI: 10.1016/j.chom.2014.06.005
Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source
Abstract
Much of the mortality attributed to influenza virus is due to secondary bacterial pneumonia, particularly from Streptococcus pneumoniae. However, mechanisms underlying this coinfection are incompletely understood. We find that prior influenza infection enhances pneumococcal colonization of the murine nasopharynx, which in turn promotes bacterial spread to the lungs. Influenza accelerates bacterial replication in vivo, and sialic acid, a major component of airway glycoconjugates, is identified as the host-derived metabolite that stimulates pneumococcal proliferation. Influenza infection increases sialic acid and sialylated mucin availability and enhances desialylation of host glycoconjugates. Pneumococcal genes for sialic acid catabolism are required for influenza to promote bacterial growth. Decreasing sialic acid availability in vivo by genetic deletion of the major airway mucin Muc5ac or mucolytic treatment limits influenza-induced pneumococcal replication. Our findings suggest that higher rates of disease during coinfection could stem from influenza-provided sialic acid, which increases pneumococcal proliferation, colonization, and aspiration.
Copyright © 2014 Elsevier Inc. All rights reserved.
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Comment in
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The public health policy implications of understanding metabiosis.Cell Host Microbe. 2014 Jul 9;16(1):3-4. doi: 10.1016/j.chom.2014.06.010. Cell Host Microbe. 2014. PMID: 25011101
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Bacterial pathogenesis: Pneumococci find a sugar daddy in influenza.Nat Rev Microbiol. 2014 Sep;12(9):596. doi: 10.1038/nrmicro3329. Epub 2014 Jul 21. Nat Rev Microbiol. 2014. PMID: 25043161 No abstract available.
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