Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation
- PMID: 25100062
- PMCID: PMC4159757
- DOI: 10.1016/j.cmet.2014.07.014
Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation
Abstract
The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc's regulation of cell physiology.
Copyright © 2014 Elsevier Inc. All rights reserved.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4159757/bin/nihms616921f1.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4159757/bin/nihms616921f2.gif)
Similar articles
-
Nutrient regulation of signaling and transcription.J Biol Chem. 2019 Feb 15;294(7):2211-2231. doi: 10.1074/jbc.AW119.003226. Epub 2019 Jan 9. J Biol Chem. 2019. PMID: 30626734 Free PMC article. Review.
-
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease.Annu Rev Biochem. 2011;80:825-58. doi: 10.1146/annurev-biochem-060608-102511. Annu Rev Biochem. 2011. PMID: 21391816 Free PMC article. Review.
-
Minireview series on the thirtieth anniversary of research on O-GlcNAcylation of nuclear and cytoplasmic proteins: Nutrient regulation of cellular metabolism and physiology by O-GlcNAcylation.J Biol Chem. 2014 Dec 12;289(50):34422-3. doi: 10.1074/jbc.R114.609776. Epub 2014 Oct 21. J Biol Chem. 2014. PMID: 25336646 Free PMC article.
-
Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity.Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E17-28. doi: 10.1152/ajpendo.90281.2008. Epub 2008 Apr 29. Am J Physiol Endocrinol Metab. 2008. PMID: 18445751 Free PMC article. Review.
-
O-GlcNAc signaling: a metabolic link between diabetes and cancer?Trends Biochem Sci. 2010 Oct;35(10):547-55. doi: 10.1016/j.tibs.2010.04.005. Epub 2010 May 11. Trends Biochem Sci. 2010. PMID: 20466550 Free PMC article. Review.
Cited by
-
The modulation of the hexosamine biosynthetic pathway impacts the localization of CD36 in macrophages.Acta Biochim Pol. 2024 Jul 8;71:13004. doi: 10.3389/abp.2024.13004. eCollection 2024. Acta Biochim Pol. 2024. PMID: 39041003 Free PMC article.
-
O-GlcNAcase regulates pluripotency states of human embryonic stem cells.Stem Cell Reports. 2024 Jul 9;19(7):993-1009. doi: 10.1016/j.stemcr.2024.05.009. Epub 2024 Jun 27. Stem Cell Reports. 2024. PMID: 38942028 Free PMC article.
-
The OGT-c-Myc-PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth.Cell Death Differ. 2024 May 22. doi: 10.1038/s41418-024-01315-4. Online ahead of print. Cell Death Differ. 2024. PMID: 38778217
-
Dissecting OGT's TPR domain to identify determinants of cellular function.Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2401729121. doi: 10.1073/pnas.2401729121. Epub 2024 May 20. Proc Natl Acad Sci U S A. 2024. PMID: 38768345
-
Changes in transcriptomic landscape with macronutrients intake switch are independent from O-GlcNAcylation levels in heart throughout postnatal development in rats.Heliyon. 2024 Apr 30;10(9):e30526. doi: 10.1016/j.heliyon.2024.e30526. eCollection 2024 May 15. Heliyon. 2024. PMID: 38737268 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources