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. 2015 Jan;43(Database issue):D193-6.
doi: 10.1093/nar/gku1173. Epub 2014 Nov 15.

LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression

Qinghua Jiang  1 , Jixuan Wang  2 , Xiaoliang Wu  3 , Rui Ma  3 , Tianjiao Zhang  3 , Shuilin Jin  4 , Zhijie Han  1 , Renjie Tan  3 , Jiajie Peng  3 , Guiyou Liu  5 , Yu Li  1 , Yadong Wang  6
Affiliations

LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression

Qinghua Jiang et al. Nucleic Acids Res. 2015 Jan.

Abstract

Long non-coding RNAs (lncRNAs) have emerged as critical regulators of genes at epigenetic, transcriptional and post-transcriptional levels, yet what genes are regulated by a specific lncRNA remains to be characterized. To assess the effects of the lncRNA on gene expression, an increasing number of researchers profiled the genome-wide or individual gene expression level change after knocking down or overexpressing the lncRNA. Herein, we describe a curated database named LncRNA2Target, which stores lncRNA-to-target genes and is publicly accessible at http://www.lncrna2target.org. A gene was considered as a target of a lncRNA if it is differentially expressed after the lncRNA knockdown or overexpression. LncRNA2Target provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene. Both search types are performed either by browsing a provided catalog of lncRNA names or by inserting lncRNA/target gene IDs/names in a search box.

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Figures

Figure 1.
Figure 1.
Screenshot of how to browse the target genes of lncRNA ‘INRIL’.
Figure 2.
Figure 2.
Screenshot of how to search target genes of lncRNA of interest or all lncRNAs that regulate a specific target gene.
See this image and copyright information in PMC

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