Effects of treadmill exercise on muscle fibers in mice with steroid myopathy
- PMID: 25792922
- PMCID: PMC4347428
- DOI: 10.1298/jjpta.4.25
Effects of treadmill exercise on muscle fibers in mice with steroid myopathy
Abstract
We studied the effect of treadmill exercise on muscle fibers in mice with experimental steroid myopathy. Frozen sections of the extensor digitorum longus (EDL) and soleus (SOL) muscles were stained with hematoxylin-eosin, and the muscle fiber diameters measured. In the EDL, muscle fiber diameters in the steroid groups decreased significantly compared with those in the control groups; moreover, muscle fiber diameters in the exercise groups increased significantly compared with those in the non-exercise groups, whereas the diameters in the SOL did not differ. We speculate that treadmill exercise may prevent corticosteroid-induced muscle fiber atrophy.
Keywords: exercise; muscle fiber; steroid myopathy.
Figures
![Fig. 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4347428/bin/jjpta-4-25-g001.gif)
Similar articles
-
Strenuous exercise-induced alterations of muscle fiber cross-sectional area and fiber-type distribution in steroid myopathy rats.Am J Phys Med Rehabil. 2008 Feb;87(2):126-33. doi: 10.1097/PHM.0b013e31815869d0. Am J Phys Med Rehabil. 2008. PMID: 17993993
-
Influence of exercise on muscle fibers in rats with steroid myopathy.Acta Med Okayama. 1999 Dec;53(6):265-70. doi: 10.18926/AMO/31621. Acta Med Okayama. 1999. PMID: 10631381
-
Pathologic changes and contractile properties of the diaphragm in corticosteroid myopathy in hamsters: comparison to peripheral muscle.Am J Respir Cell Mol Biol. 1989 Sep;1(3):191-9. doi: 10.1165/ajrcmb/1.3.191. Am J Respir Cell Mol Biol. 1989. PMID: 2624759
-
Effects of ageing and exercise on soleus and extensor digitorum longus muscles of female rats.Mech Ageing Dev. 1992 Mar 15;63(1):69-77. doi: 10.1016/0047-6374(92)90017-8. Mech Ageing Dev. 1992. PMID: 1602840
-
Resistance to rocuronium of rat diaphragm as compared with limb muscles.J Surg Res. 2014 Dec;192(2):471-9. doi: 10.1016/j.jss.2014.07.017. Epub 2014 Jul 16. J Surg Res. 2014. PMID: 25112806
Cited by
-
Stuart has got the PoWeR! Skeletal muscle adaptations to a novel heavy progressive weighted wheel running exercise model in C57BL/6 mice.Exp Physiol. 2024 Feb;109(2):271-282. doi: 10.1113/EP091494. Epub 2023 Nov 16. Exp Physiol. 2024. PMID: 37974360 Free PMC article.
-
Effect of acute treadmill exercise on cisplatin-induced muscle atrophy in the mouse.Pflugers Arch. 2017 Nov;469(11):1495-1505. doi: 10.1007/s00424-017-2045-4. Epub 2017 Jul 31. Pflugers Arch. 2017. PMID: 28762162
References
-
- Perkoff GT, Sillber R, et al. : Studies in disorders of muscle. XII. Myopathy due to the administration of therapeutic amounts of 17-hydroxycorticosteroids. Am J Med 26: 891-898, 1959. - PubMed
-
- Afifi AK, Bergman RA, et al. : Steroid myopathy. Clinical, historical and cytological observations. Johns Hopkins Med J 123: 158-174, 1969. - PubMed
-
- Apte KS: Rehabilitation of patients with quadriparesis after treatment of status asthmaticus with neuromuscular blocking agents and high dose corticosteroids. Arch Phys Med Rehabil 72: 1024-1028, 1991. - PubMed
-
- Decramer M: Corticosteroid-induced myopathy involving respiratory muscles on patients with chronic obstructive pulmonary disease or asthma. Am Rev Respir Dis 146: 800-802, 1992. - PubMed
-
- Saltin B, Gollnick PD: Skeletal muscle adaptability: Significance for metabolism and performance. In: Peachey LD. (ed) Handbook of Physiology. 1st ed, American Physiological Society. Williams & Wilkins, Baltimore, 1983, pp 555-631.
LinkOut - more resources
Full Text Sources