Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2015 Mar 30:15:202.
doi: 10.1186/s12885-015-1218-9.

Meta-analysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer

Xuanzhang Huang  1 , Peng Gao  2 , Yongxi Song  3 , Jingxu Sun  4 , Xiaowan Chen  5 , Junhua Zhao  6 , Huimian Xu  7 , Zhenning Wang  8
Affiliations
Meta-Analysis

Meta-analysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer

Xuanzhang Huang et al. BMC Cancer. .

Abstract

Background: The prognostic value of circulating tumor cells (CTCs) detected with the CellSearch System in patients with colorectal cancer (CRC) is controversial. The aim of our meta-analysis was to evaluate whether the detection of CTCs in the peripheral blood with the standardized CellSearch System has prognostic utility for patients with CRC.

Methods: The PubMed, Science Citation Index, Cochrane Database, Embase, and the references in relevant studies were systematically searched (up to December, 2014). No search restrictions were imposed. Our meta-analysis was performed in Stata software, version 12.0 (2011) (Stata Corp, College Station, TX, USA), with the odds ratio (OR), risk ratio (RR), hazard ratio (HR), and 95% confidence interval (95% CI) as the effect measures. Subgroup and sensitivity analyses were also conducted.

Results: Eleven studies containing 1847 patients with CRC were analyzed. There was a significantly higher incidence of CTCs in the metastasis-positive group than in the metastasis-negative group (OR = 4.06, 95% CI [1.74, 9.50], P < 0.01, I(2) = 0%). For hepatic metastasis, a type of metastasis, a higher incidence of CTCs was observed in the hepatic-metastasis-positive group than in the -negative group (OR = 2.61, 95% CI [1.73, 3.96], P < 0.01, I(2) = 0%). The presence of CTCs was significantly related to overall survival (HR = 2.00, 95% CI [1.49, 2.69], P < 0.01, I(2) = 67.1%) and progression-free survival (HR = 1.80, 95% CI [1.52, 2.13], P < 0.01, I(2) = 43.9%) of patients with CRC, regardless of the sampling time. The response rate for the CTC(+) groups was significantly lower than that for the CTC(-) groups at baseline and during treatment (baseline: 33% versus 39%, RR = 0.79, 95% CI [0.63, 0.99], P = 0.04, I(2) = 7.0%; during treatment: 17% versus 46%, RR = 0.41, 95% CI [0.22, 0.77], P = 0.01, I(2) = 0.0%;).

Conclusions: Our meta-analysis indicates that the detection of CTCs in the peripheral blood with the CellSearch System has prognostic utility for patients with CRC.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Selection of studies. Flow chart showing the selection process for the including studies.
Figure 2
Figure 2
Odds ratios summary for all kinds of tumor metastasis (A) and hepatic metastasis (B). A: The estimated odds ratio (OR) was summarized for the relationship between all kinds of tumor metastasis and CTC detection. B: The OR was summarized for the relationship between hepatic metastasis and CTC detection.
Figure 3
Figure 3
Hazard ratios summary for overall survival (A) and progression-free survival (B). A: The estimated hazard ratio (HR) was summarized for overall survival with CTC detection. B: The estimated HR was summarized for progression-free survival with CTC detection.
Figure 4
Figure 4
Risk ratios summary for the correlation of tumor response and CTCs. A: The estimated risk ratio (RR) was summarized for the correlation of tumor response with CTCs detected at baseline time. B: The estimated RR was summarized for the correlation of tumor response with CTCs detected at during-treatment time.
Figure 5
Figure 5
Funnel plot analysis. A: overall survival; B: progression-free survival. A: Funnel plot of the studies on overall survival. B: Funnel plot of the studies on progression-free survival.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90. doi: 10.3322/caac.20107. - DOI - PubMed
    1. Seymour MT, Maughan TS, Ledermann JA, Topham C, James R, Gwyther SJ, et al. Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial. Lancet. 2007;370(9582):143–52. doi: 10.1016/S0140-6736(07)61087-3. - DOI - PubMed
    1. Shah SA, Haddad R, Al-Sukhni W, Kim RD, Greig PD, Grant DR, et al. Surgical resection of hepatic and pulmonary metastases from colorectal carcinoma. J Am Coll Surg. 2006;202(3):468–75. doi: 10.1016/j.jamcollsurg.2005.11.008. - DOI - PubMed
    1. Fidler IJ. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer. 2003;3(6):453–8. doi: 10.1038/nrc1098. - DOI - PubMed
    1. Chen WS, Chung MY, Liu JH, Liu JM, Lin JK. Impact of circulating free tumor cells in the peripheral blood of colorectal cancer patients during laparoscopic surgery. World J Surg. 2004;28(6):552–7. doi: 10.1007/s00268-004-7276-9. - DOI - PubMed

Publication types

-