Relationship between CYP17A1 genetic polymorphism and coronary artery disease in a Chinese Han population
- PMID: 25889125
- PMCID: PMC4359393
- DOI: 10.1186/s12944-015-0007-4
Relationship between CYP17A1 genetic polymorphism and coronary artery disease in a Chinese Han population
Abstract
Background: CYP17A1 gene encodes P450c17 proteins, which is a key enzyme that catalyzes the formation of sex hormones. Many clinical studies showed that sex hormones levels play an important role in the pathogenesis of coronary artery disease (CAD). However, the relationship between CYP17A1 genetic polymorphisms and CAD remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with CAD in a Han population of China.
Methods: A total of 997 people include 490 patients and 507 controls were selected for the present study. Five single-nucleotide polymorphisms (SNPs) (rs4919686, rs1004467, rs4919687, rs10786712, and rs2486758) were genotyped by using the real-time PCR (TaqMan) method.
Results: For men, the rs10786712 was found to be associated with CAD in a recessive model (P=0.016), after adjustment of the major confounding factors, the significant difference was retained (OR=1.644, 95% confidence interval [CI]: 1.087-2.488, P=0.019). For women, the rs1004467 was also found to be associated with CAD in a dominant model (P=0.038), the difference remained statistically significant after multivariate adjustment (OR=1.623, 95% CI: 1.023-2.576, P=0.040). The distribution of rs4919687 genotypes showed a significant difference between CAD and control participants in a recessive model (P=0.019), the significant difference was retained after adjustment for covariates (OR=0.417, 95% CI: 0.188-0.926, P=0.032).
Conclusion: Rs1004467, rs4919687, rs10786712 of CYP17A1 gene are associated with CAD in Han population of China. The TT genotype of rs10786712 could be a protective genetic marker of CAD in men. The CC genotype of rs1004467 and the AA genotype of rs4919687 could be risk genetic markers of CAD in women. However, large sample size study including other SNPs of CYP17A1 should be performed in future studies.
Similar articles
-
Polymorphisms of TRIB1 genes for coronary artery disease and stroke risk: A systematic review and meta-analysis.Gene. 2023 Sep 5;880:147613. doi: 10.1016/j.gene.2023.147613. Epub 2023 Jul 4. Gene. 2023. PMID: 37414350 Review.
-
Exploration of CYP21A2 and CYP17A1 polymorphisms and preeclampsia risk among Chinese Han population: a large-scale case-control study based on 5021 subjects.Hum Genomics. 2020 Sep 25;14(1):33. doi: 10.1186/s40246-020-00286-0. Hum Genomics. 2020. PMID: 32977860 Free PMC article.
-
CYP17A1 Polymorphisms Are Linked to the Risk of Coronary Heart Disease in a Case-Control Study.J Cardiovasc Pharmacol. 2019 Aug;74(2):98-104. doi: 10.1097/FJC.0000000000000687. J Cardiovasc Pharmacol. 2019. PMID: 31356544
-
Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population.Aging Dis. 2015 Nov 17;6(6):486-98. doi: 10.14336/AD.2015.0505. eCollection 2015 Nov. Aging Dis. 2015. PMID: 26618050 Free PMC article.
-
Haplotype analyses of CYP17A1 genetic polymorphisms and coronary artery disease in a Uygur population.J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):389-98. doi: 10.1177/1470320314565840. Epub 2015 Jan 14. J Renin Angiotensin Aldosterone Syst. 2015. PMID: 25592814
Cited by
-
Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease.Cell Commun Signal. 2023 Jun 27;21(1):155. doi: 10.1186/s12964-023-01061-z. Cell Commun Signal. 2023. PMID: 37370070 Free PMC article.
-
Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment.J Med Chem. 2023 May 25;66(10):6542-6566. doi: 10.1021/acs.jmedchem.3c00442. Epub 2023 May 16. J Med Chem. 2023. PMID: 37191389 Free PMC article. Review.
-
Abiraterone and enzalutamide had different adverse effects on the cardiovascular system: a systematic review with pairwise and network meta-analyses.Prostate Cancer Prostatic Dis. 2021 Mar;24(1):244-252. doi: 10.1038/s41391-020-00275-3. Epub 2020 Aug 28. Prostate Cancer Prostatic Dis. 2021. PMID: 32860011
-
CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development.Sci Rep. 2020 May 29;10(1):8792. doi: 10.1038/s41598-020-65601-0. Sci Rep. 2020. PMID: 32472014 Free PMC article.
-
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.Front Endocrinol (Lausanne). 2018 Jun 11;9:323. doi: 10.3389/fendo.2018.00323. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 29942286 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous