Aging of skeletal muscle fibers
- PMID: 25932410
- PMCID: PMC4414960
- DOI: 10.5535/arm.2015.39.2.155
Aging of skeletal muscle fibers
Abstract
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional capacity and independence. Sarcopenia is partly responsible for this decline. Many changes underlying the loss of muscle mass and force-generating capacity of skeletal muscle can be understood at the cellular and molecular levels. Muscle size and architecture are both altered with advanced adult age. Further, changes in myofibers include impairments in several physiological domains including muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, and repair and regeneration. A thorough understanding of these alterations can lead to the design of improved preventative and rehabilitative interventions, such as personalized exercise training programs.
Keywords: Elderly; Myofilament; Sarcopenia.
Conflict of interest statement
Figures
Similar articles
-
Rehabilitation of Older Adults with Sarcopenia: From Cell to Functioning.Prog Rehabil Med. 2022 Sep 3;7:20220044. doi: 10.2490/prm.20220044. eCollection 2022. Prog Rehabil Med. 2022. PMID: 36118146 Free PMC article. Review.
-
Moderate-intensity resistance exercise alters skeletal muscle molecular and cellular structure and function in inactive older adults with knee osteoarthritis.J Appl Physiol (1985). 2017 Apr 1;122(4):775-787. doi: 10.1152/japplphysiol.00830.2016. Epub 2017 Jan 12. J Appl Physiol (1985). 2017. PMID: 28082334 Free PMC article.
-
Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans.Front Physiol. 2014 Sep 26;5:369. doi: 10.3389/fphys.2014.00369. eCollection 2014. Front Physiol. 2014. PMID: 25309456 Free PMC article. Review.
-
Muscle mechanics: adaptations with exercise-training.Exerc Sport Sci Rev. 1996;24:427-73. Exerc Sport Sci Rev. 1996. PMID: 8744258 Review.
-
The role of progressive resistance training and nutrition in the preservation of lean body mass in the elderly.J Am Coll Nutr. 1995 Dec;14(6):587-94. doi: 10.1080/07315724.1995.10718547. J Am Coll Nutr. 1995. PMID: 8598419 Review.
Cited by
-
Examining the mediating role of muscle quantity in adolescents: associations with adiposity, cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors.Sci Rep. 2024 May 26;14(1):12030. doi: 10.1038/s41598-024-61805-w. Sci Rep. 2024. PMID: 38797741 Free PMC article.
-
Examining variations in body composition among patients with colorectal cancer according to site and disease stage.Sci Rep. 2024 May 11;14(1):10829. doi: 10.1038/s41598-024-61790-0. Sci Rep. 2024. PMID: 38734789 Free PMC article.
-
Muscle fibre size and myonuclear positioning in trained and aged humans.Exp Physiol. 2024 Apr;109(4):549-561. doi: 10.1113/EP091567. Epub 2024 Mar 10. Exp Physiol. 2024. PMID: 38461483 Free PMC article.
-
Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage.Cells. 2024 Jan 30;13(3):255. doi: 10.3390/cells13030255. Cells. 2024. PMID: 38334647 Free PMC article. Review.
-
Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice.Biogerontology. 2024 Jun;25(3):447-459. doi: 10.1007/s10522-023-10086-3. Epub 2024 Jan 6. Biogerontology. 2024. PMID: 38183523
References
-
- World Health Organization [Internet] Geneva: World Health Organization; c2015. [cited 2015 Feb 16]. Available from: http://www.who.int/
-
- Countryeconomy.com [Internet] [place unknown]: Countryeconomy.com; c2015. [cited 2015 Feb 16]. Available from: http://countryeconomy.com/
-
- Brady AO, Straight CR, Evans EM. Body composition, muscle capacity, and physical function in older adults: an integrated conceptual model. J Aging Phys Act. 2014;22:441–452. - PubMed
-
- Gill TM, Allore HG, Hardy SE, Guo Z. The dynamic nature of mobility disability in older persons. J Am Geriatr Soc. 2006;54:248–254. - PubMed
-
- Gill TM, Kurland B. The burden and patterns of disability in activities of daily living among community-living older persons. J Gerontol A Biol Sci Med Sci. 2003;58:70–75. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources