The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming
- PMID: 26250599
- PMCID: PMC4677129
- DOI: 10.1038/npp.2015.231
The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming
Abstract
Adversity experienced during gestation is a predictor of lifetime neuropsychiatric disease susceptibility. Specifically, maternal stress during pregnancy predisposes offspring to sex-biased neurodevelopmental disorders, including schizophrenia, attention deficit/hyperactivity disorder, and autism spectrum disorders. Animal models have demonstrated disease-relevant endophenotypes in prenatally stressed offspring and have provided unique insight into potential programmatic mechanisms. The placenta has a critical role in the deleterious and sex-specific effects of maternal stress and other fetal exposures on the developing brain. Stress-induced perturbations of the maternal milieu are conveyed to the embryo via the placenta, the maternal-fetal intermediary responsible for maintaining intrauterine homeostasis. Disruption of vital placental functions can have a significant impact on fetal development, including the brain, outcomes that are largely sex-specific. Here we review the novel involvement of the placenta in the transmission of the maternal adverse environment and effects on the developing brain.
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References
-
- Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF (2002). Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277: 1531–1537. - PubMed
-
- Andersen SL (2003). Trajectories of brain development: point of vulnerability or window of opportunity? Neurosci Biobehav Rev 27: 3–18. - PubMed
-
- Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ (2007). Placental trophoblast inclusions in autism spectrum disorder. Biol Psychiatry 61: 487–491. - PubMed
-
- Arck PC, Hecher K (2013). Fetomaternal immune cross-talk and its consequences for maternal and offspring's health. Nat Med 19: 548–556. - PubMed
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