The Role of Cytokines and Chemokines in Filovirus Infection
- PMID: 26512687
- PMCID: PMC4632400
- DOI: 10.3390/v7102892
The Role of Cytokines and Chemokines in Filovirus Infection
Abstract
Ebola- and marburgviruses are highly pathogenic filoviruses and causative agents of viral hemorrhagic fever. Filovirus disease is characterized by a dysregulated immune response, severe organ damage, and coagulation abnormalities. This includes modulation of cytokines, signaling mediators that regulate various components of the immune system as well as other biological processes. Here we examine the role of cytokines in filovirus infection, with an emphasis on understanding how these molecules affect development of the antiviral immune response and influence pathology. These proteins may present targets for immune modulation by therapeutic agents and vaccines in an effort to boost the natural immune response to infection and/or reduce immunopathology.
Keywords: Ebola; Filovirus; Marburg; chemokine; cytokine; immunopathology.
Figures
Similar articles
-
The structural basis for filovirus neutralization by monoclonal antibodies.Curr Opin Immunol. 2018 Aug;53:196-202. doi: 10.1016/j.coi.2018.05.001. Epub 2018 Jun 22. Curr Opin Immunol. 2018. PMID: 29940415 Free PMC article. Review.
-
Rodent-Adapted Filoviruses and the Molecular Basis of Pathogenesis.J Mol Biol. 2016 Aug 28;428(17):3449-66. doi: 10.1016/j.jmb.2016.05.008. Epub 2016 May 14. J Mol Biol. 2016. PMID: 27189922 Free PMC article. Review.
-
Filoviruses: One of These Things is (not) Like the Other.Viruses. 2015 Sep 29;7(10):5172-90. doi: 10.3390/v7102867. Viruses. 2015. PMID: 26426036 Free PMC article. Review.
-
Correlates of immunity to filovirus infection.Viruses. 2011 Jul;3(7):982-1000. doi: 10.3390/v3070982. Epub 2011 Jun 27. Viruses. 2011. PMID: 21994766 Free PMC article. Review.
-
Filoviruses and the balance of innate, adaptive, and inflammatory responses.Viral Immunol. 2006 Winter;19(4):602-12. doi: 10.1089/vim.2006.19.602. Viral Immunol. 2006. PMID: 17201655 Review.
Cited by
-
Novel antiviral approaches for Marburg: a promising therapeutics in the pipeline.Front Microbiol. 2024 Apr 25;15:1387628. doi: 10.3389/fmicb.2024.1387628. eCollection 2024. Front Microbiol. 2024. PMID: 38725678 Free PMC article. Review.
-
Coordinated inflammatory responses dictate Marburg virus control by reservoir bats.Nat Commun. 2024 Feb 28;15(1):1826. doi: 10.1038/s41467-024-46226-7. Nat Commun. 2024. PMID: 38418477 Free PMC article.
-
Peripheral immune responses to filoviruses in a reservoir versus spillover hosts reveal transcriptional correlates of disease.Front Immunol. 2024 Jan 8;14:1306501. doi: 10.3389/fimmu.2023.1306501. eCollection 2023. Front Immunol. 2024. PMID: 38259437 Free PMC article.
-
Ebola Virus Uses Tunneling Nanotubes as an Alternate Route of Dissemination.J Infect Dis. 2023 Nov 13;228(Suppl 7):S522-S535. doi: 10.1093/infdis/jiad400. J Infect Dis. 2023. PMID: 37723997 Free PMC article.
-
Development of tolerance to chemokine receptor antagonists: current paradigms and the need for further investigation.Front Immunol. 2023 Jul 28;14:1184014. doi: 10.3389/fimmu.2023.1184014. eCollection 2023. Front Immunol. 2023. PMID: 37575219 Free PMC article. Review.
References
-
- Kuhn J.H., Becker S., Ebihara H., Geisbert T.W., Johnson K.M., Kawaoka Y., Lipkin W.I., Negredo A.I., Netesov S.V., Nichol S.T., et al. Proposal for a revised taxonomy of the family Filoviridae: Classification, names of taxa and viruses, and virus abbreviations. Arch. Virol. 2010;155:2083–2103. - PMC - PubMed
-
- Martini G.A., Siegert R. Marburg Virus Disease. Springer; New York, NY, USA: 1971.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources