Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh
- PMID: 26516891
- PMCID: PMC4661611
- DOI: 10.3390/ijerph121113739
Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh
Abstract
In earlier analyses, we demonstrated dose-response relationships between renal and lung cancer and local arsenic concentrations in wells used by Bangladeshi villagers. We used the same case-referent approach to examine the relation of arsenic to biopsy confirmed transition cell cancer (TCC) of the ureter, bladder or urethra in these villagers. As the International Agency for Research on Cancer (IARC) has conclude that arsenic in drinking water causes bladder cancer, we expected to find higher risk with increasing arsenic concentration. We used histology/cytology results from biopsies carried out at a single clinic in Dhaka, Bangladesh from January 2008 to October 2011. We classified these into four groups, TCC (n = 1466), other malignancies (n = 145), chronic cystitis (CC) (n = 844) and other benign (n = 194). Arsenic concentration was estimated from British Geological Survey reports. Odds ratios were calculated by multilevel logistic regression adjusted for confounding and allowing for geographic clustering. We found no consistent trend for TCC with increasing arsenic concentration but the likelihood of a patient with benign disease having CC was significantly increased at arsenic concentrations >100 µg/L. We conclude that the expected relationship of TCC to arsenic was masked by over-matching that resulted from the previously unreported relationship between arsenic and CC. We hypothesize that CC may be a precursor of TCC in high arsenic areas.
Keywords: Bangladesh; arsenic; chronic cystitis; drinking water; over-matching; transition cell cancer.
Figures
Similar articles
-
Histopathology of Cervical Cancer and Arsenic Concentration in Well Water: An Ecological Analysis.Int J Environ Res Public Health. 2017 Oct 6;14(10):1185. doi: 10.3390/ijerph14101185. Int J Environ Res Public Health. 2017. PMID: 28984820 Free PMC article.
-
Arsenic in drinking water and renal cancers in rural Bangladesh.Occup Environ Med. 2013 Nov;70(11):768-73. doi: 10.1136/oemed-2013-101443. Epub 2013 Aug 28. Occup Environ Med. 2013. PMID: 24143018
-
Groundwater arsenic and education attainment in Bangladesh.J Health Popul Nutr. 2015 Oct 26;33:20. doi: 10.1186/s41043-015-0029-6. J Health Popul Nutr. 2015. PMID: 26825054 Free PMC article.
-
Magnitude of arsenic toxicity in tube-well drinking water in Bangladesh and its adverse effects on human health including cancer: evidence from a review of the literature.Asian Pac J Cancer Prev. 2003 Jan-Mar;4(1):7-14. Asian Pac J Cancer Prev. 2003. PMID: 12718695 Review.
-
Bladder cancer and arsenic through drinking water: a systematic review of epidemiologic evidence.J Environ Sci Health A Tox Hazard Subst Environ Eng. 2013;48(14):1764-75. doi: 10.1080/10934529.2013.823329. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2013. PMID: 24007431 Review.
Cited by
-
Update of the risk assessment of inorganic arsenic in food.EFSA J. 2024 Jan 18;22(1):e8488. doi: 10.2903/j.efsa.2024.8488. eCollection 2024 Jan. EFSA J. 2024. PMID: 38239496 Free PMC article.
-
Arsenic is a potent co-mutagen of ultraviolet light.Commun Biol. 2023 Dec 16;6(1):1273. doi: 10.1038/s42003-023-05659-4. Commun Biol. 2023. PMID: 38104187 Free PMC article.
-
A Comparative Study of Water Quality and Human Health Risk Assessment in Longevity Area and Adjacent Non-Longevity Area.Int J Environ Res Public Health. 2019 Oct 4;16(19):3737. doi: 10.3390/ijerph16193737. Int J Environ Res Public Health. 2019. PMID: 31590212 Free PMC article.
-
Low-Level Exposure to Arsenic in Drinking Water and Risk of Lung and Bladder Cancer: A Systematic Review and Dose-Response Meta-Analysis.Dose Response. 2019 Jul 22;17(3):1559325819863634. doi: 10.1177/1559325819863634. eCollection 2019 Jul-Sep. Dose Response. 2019. PMID: 31384239 Free PMC article.
-
Histopathology of Cervical Cancer and Arsenic Concentration in Well Water: An Ecological Analysis.Int J Environ Res Public Health. 2017 Oct 6;14(10):1185. doi: 10.3390/ijerph14101185. Int J Environ Res Public Health. 2017. PMID: 28984820 Free PMC article.
References
-
- Mostafa M.G., Cherry N.M. Arsenic in drinking water and renal cancers in rural Bangladesh. Occup. Environ. Med. 2013;70:768–773. - PubMed
-
- Christoforidou E.P., Riza E., Kales S.N., Hadjistavrou K., Stoltidi M., Kastania A.N., Linos A. Bladder cancer and arsenic through drinking water: A systematic review of epidemiologic evidence. J. Environ. Sci. Health Part A Toxic/Hazard. Subst. Environ. Eng. 2013;48:1764–1775. doi: 10.1080/10934529.2013.823329. - DOI - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials