Diet and Skin Cancer: The Potential Role of Dietary Antioxidants in Nonmelanoma Skin Cancer Prevention
- PMID: 26583073
- PMCID: PMC4637095
- DOI: 10.1155/2015/893149
Diet and Skin Cancer: The Potential Role of Dietary Antioxidants in Nonmelanoma Skin Cancer Prevention
Abstract
Nonmelanoma skin cancer (NMSC) is the most common cancer among Americans. Ultraviolet (UV) radiation exposure is the major risk factor for the development of NMSC. Dietary AOs may prevent free radical-mediated DNA damage and tumorigenesis secondary to UV radiation. Numerous laboratory studies have found that certain dietary AOs show significant promise in skin cancer prevention. These results have been substantiated by animal studies. In human studies, researchers have evaluated both oral AO supplements and dietary intake of AOs via whole foods. In this review, we provide an overview of the role of AOs in preventing tumorigenesis and outline four targeted dietary AOs. We review the results of research evaluating oral AOs supplements as compared to dietary AOs intake via whole foods. While these specific supplements have not shown efficacy, intake of AOs via consumption of whole foods has shown some promise. Lessons learned from the field of hypertension research may provide important guidance in future study design. Further research on the role of dietary AOs in the prevention of NMSC is warranted and should focus on intake via whole food consumption.
Similar articles
-
The hidden diet: Synthetic antioxidants in packaged food and their impact on human exposure and health.Environ Int. 2024 Apr;186:108613. doi: 10.1016/j.envint.2024.108613. Epub 2024 Mar 28. Environ Int. 2024. PMID: 38555663
-
The Role of Dietary Antioxidants in Melanoma and Nonmelanoma Skin Cancer.Cutis. 2023 Jan;111(1):33-48. doi: 10.12788/cutis.0672. Cutis. 2023. PMID: 36947767 Review.
-
Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1344-9. doi: 10.1158/1055-9965.EPI-04-0664. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 15894701
-
Dietary factors in the prevention and treatment of nonmelanoma skin cancer and melanoma.Dermatol Surg. 2002 Dec;28(12):1143-52. doi: 10.1046/j.1524-4725.2002.02114.x. Dermatol Surg. 2002. PMID: 12472495 Review.
-
Influence of dietary factors on actinically-induced skin cancer.Mutat Res. 1998 Nov 9;422(1):185-90. doi: 10.1016/s0027-5107(98)00191-2. Mutat Res. 1998. PMID: 9920444 Review.
Cited by
-
Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment.Molecules. 2024 Feb 4;29(3):728. doi: 10.3390/molecules29030728. Molecules. 2024. PMID: 38338469 Free PMC article. Review.
-
Global trends of cancer: The role of diet, lifestyle, and environmental factors.Cancer Innov. 2023 Jul 25;2(4):290-301. doi: 10.1002/cai2.76. eCollection 2023 Aug. Cancer Innov. 2023. PMID: 38089751 Free PMC article. Review.
-
Influence of environmental risk factors on the development of wounds associated with squamous cell carcinoma.Int Wound J. 2023 Nov 27;21(3):e14506. doi: 10.1111/iwj.14506. Online ahead of print. Int Wound J. 2023. PMID: 38010070 Free PMC article.
-
Functional Foods in Dermatology.Dermatol Pract Concept. 2023 Oct 1;13(4):e2023256. doi: 10.5826/dpc.1304a256. Dermatol Pract Concept. 2023. PMID: 37992371 Free PMC article. Review.
-
A registration trend in eyelid skin cancers and associated risk factors in Iran, 2005-2016.BMC Cancer. 2023 Sep 30;23(1):924. doi: 10.1186/s12885-023-11414-z. BMC Cancer. 2023. PMID: 37777736 Free PMC article.
References
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources