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. 2016 Jan:69:44-51.
doi: 10.1016/j.molimm.2015.10.017. Epub 2015 Dec 3.

BIP induces mice CD19(hi) regulatory B cells producing IL-10 and highly expressing PD-L1, FasL

Youfa Tang  1 , Qing Jiang  1 , Yanghui Ou  1 , Fan Zhang  1 , Kai Qing  1 , Yuanli Sun  1 , Wenjie Lu  2 , Huifen Zhu  1 , Feili Gong  1 , Ping Lei  3 , Guanxin Shen  1
Affiliations

BIP induces mice CD19(hi) regulatory B cells producing IL-10 and highly expressing PD-L1, FasL

Youfa Tang et al. Mol Immunol. 2016 Jan.

Abstract

Many studies have shown that B cells possess a regulatory function in mouse models of autoimmune diseases. Regulatory B cells can modulate immune response through many types of molecular mechanisms, including the production of IL-10 and the expression of PD-1 Ligand and Fas Ligand, but the microenvironmental factors and mechanisms that induce regulatory B cells have not been fully identified. BIP (binding immunoglobulin protein), a member of the heat shock protein 70 family, is a type of evolutionarily highly conserved protein. In this article, we have found that IL-10(+), PD-L1(hi) and FasL(hi) B cells are discrete cell populations, but enriched in CD19(hi) cells. BIP can induce IL-10-producing splenic B cells, IL-10 secretion and B cells highly expressing PD-L1 and FasL. CD40 signaling acts in synergy with BIP to induce regulatory B cells. BIP increased surface CD19 molecule expression intensity and IL-10(+), PD-L1(hi) and FasL(hi) B cells induced by BIP share the CD19(hi) phenotype. Furthermore, B cells treated with BIP and anti-CD40 can lead to suppression of T cell proliferation and the effect is partially IL-10-dependent and mainly BIP-induced. Taken together, our findings identify a novel function of BIP in the induction of regulatory B cells and add a new reason for the therapy of autoimmune disorders or other inflammatory conditions.

Keywords: BIP; FasL; IL-10; PD-L1; Regulatory B cells.

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