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. 2016 Jan 22;469(4):985-92.
doi: 10.1016/j.bbrc.2015.12.078. Epub 2015 Dec 22.

LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer

Fujin Jiang  1 , Song Ma  2 , Yubao Xue  3 , Jianquan Hou  4 , Yongjie Zhang  5
Affiliations

LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer

Fujin Jiang et al. Biochem Biophys Res Commun. .

Abstract

Lactate dehydrogenase-A(LDH-A) is an important rate-limiting enzyme in the Warburg effect. Survival analysis indicated poor clinical outcomes in MIBC with high LDH-A expression. The results of in vitro experiment indicated that LDH-A promotes MIBC cells proliferation, invasion and migration. The positive relationship between LDH-A expression and CSC/EMT markers was confirmed both in invasive bladder cell line and in 136 MIBC specimens. Thus, we conclude that LDH-A may be a promising target for MIBC.

Keywords: E-cadherin; Epithelial-to-mesenchymal transition; Histone deacetylases; Lactate dehydrogenase-A; Muscle-invasive bladder cancer; Oct4.

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