Paraoxonase-1 and arylesterase activities in patients with colorectal cancer

. 2015 Nov 15;8(11):21599-604.

eCollection 2015.

Paraoxonase-1 and arylesterase activities in patients with colorectal cancer

Cigdem Usul Afsar¹, Meral Gunaldı², Yıldız Okuturlar³, Asuman Gedikbası⁴, Elif Eda Tiken⁵, Sibel Kahraman⁶, Feryal Karaca⁷, Vehbi Ercolak⁸, Mehmet Karabulut⁹

Affiliations

¹ Department of Medical Oncology, Istanbul Education and Research Hospital Istanbul, Turkey.
² Department of Medical Oncology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
³ Department of Internal Medicine, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
⁴ Department of Biochemistry, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
⁵ Department of Radiation Oncology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
⁶ Department of Pathology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
⁷ Department of Radiation Oncology, Adana Numune Training and Research Hospital Adana, Turkey.
⁸ Department of Medical Oncology, Mersin Government Hospital Mersin, Turkey.
⁹ Department of General Surgery, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.

PMID: 26885111
PMCID: PMC4723956

Paraoxonase-1 and arylesterase activities in patients with colorectal cancer

Cigdem Usul Afsar et al. Int J Clin Exp Med. 2015.

. 2015 Nov 15;8(11):21599-604.

eCollection 2015.

Authors

Cigdem Usul Afsar¹, Meral Gunaldı², Yıldız Okuturlar³, Asuman Gedikbası⁴, Elif Eda Tiken⁵, Sibel Kahraman⁶, Feryal Karaca⁷, Vehbi Ercolak⁸, Mehmet Karabulut⁹

Affiliations

¹ Department of Medical Oncology, Istanbul Education and Research Hospital Istanbul, Turkey.
² Department of Medical Oncology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
³ Department of Internal Medicine, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
⁴ Department of Biochemistry, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
⁵ Department of Radiation Oncology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
⁶ Department of Pathology, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.
⁷ Department of Radiation Oncology, Adana Numune Training and Research Hospital Adana, Turkey.
⁸ Department of Medical Oncology, Mersin Government Hospital Mersin, Turkey.
⁹ Department of General Surgery, Bakırkoy Dr Sadi Konuk Education and Research Hospital Istanbul, Turkey.

PMID: 26885111
PMCID: PMC4723956

Abstract

Background: The aim of this study was to evaluate paraoxonase-1 (PON1) and arylesterase (ARE) activities and oxidative stress status in patients with colorectal carcinomas (CRC).

Materials and methods: Thirty-three patients (20 male, 13 female) with CRC and 30 healthy controls were enrolled in the study. Blood samples were obtained from the CRC patients before adjuvant therapy. Serum samples from CRC patients and healthy controls were analyzed for PON1 and ARE activities.

Results: The PON1 and ARE activities of the patients with CRC were significantly higher compared to those of the control group (PON1 activity is 125.35±20.07 U/L for CRC patients and 1.22±0.48 U/L for control group, P<0.001; ARE activity is 160.76±10.79 U/L for CRC patients). ARE levels showed a positive correlation with smoking status (P=0.04). PON1 activity was higher in colon carcinoma patients (135.95±19.3 U/L) rather than rectal carcinoma patients (97.08±5.24 U/L) but it was not statistically significant (P=0.72).

Conclusion: Serum PON1 activity is increased in patients with CRC, and serum ARE levels showed a positive correlation with smoking status. PON1 activity was higher in colon carcinoma patients. There is no other study in literature investigating these activities for CRC patients. It should be reevaluated by larger clinical trials.

Keywords: Colorectal cancer; arylesterase; paraoxonase.

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References

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[1] Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69. - PubMed

[2] Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69. - PubMed

[3] Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology. 2010;138:2029. - PMC - PubMed

[4] Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology. 2010;138:2029. - PMC - PubMed

[5] Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 1990;323:1228. - PubMed

[6] Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 1990;323:1228. - PubMed

[7] Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S. Diabetes mellitus and the risk of cancer: results from a large-scale populationbased cohort study in Japan. Arch Intern Med. 2006;166:1871. - PubMed

[8] Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S. Diabetes mellitus and the risk of cancer: results from a large-scale populationbased cohort study in Japan. Arch Intern Med. 2006;166:1871. - PubMed

[9] Hu FB, Manson JE, Liu S, Hunter D, Colditz GA, Michels KB, Speizer FE, Giovannucci E. Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women. J Natl Cancer Inst. 1999;91:542. - PubMed

[10] Hu FB, Manson JE, Liu S, Hunter D, Colditz GA, Michels KB, Speizer FE, Giovannucci E. Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women. J Natl Cancer Inst. 1999;91:542. - PubMed

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Paraoxonase-1 and arylesterase activities in patients with colorectal cancer

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Paraoxonase-1 and arylesterase activities in patients with colorectal cancer

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