An overview of systematic reviews on the effectiveness of periodontal treatment to improve glycaemic control
- PMID: 26913689
- DOI: 10.1111/jre.12358
An overview of systematic reviews on the effectiveness of periodontal treatment to improve glycaemic control
Abstract
Several systematic reviews with meta-analyses on the effectiveness of periodontal treatment to improve glycaemic control have been published. So far no overview of these systematic reviews has been performed. The main objective of this report was to assess critically these systematic reviews to provide the reader with a high-level synthesis of research evidence. MEDLINE (via PubMed) and EMBASE databases were searched independently and in duplicate to identify systematic reviews with meta-analyses of clinical studies that assessed the relationship between diabetes mellitus and periodontitis. The last database search was performed on 10 March 2015. The reference lists of included systematic reviews were also scrutinized for further publications. The methodological quality of the included systematic reviews was assessed independently with two validated checklists (AMSTAR and OQAQ) by two authors. Disagreements in the assessment were resolved by consensus. A total of 226 potential publications were initially retrieved. Eleven systematic reviews with meta-analyses were finally included. Glycosylated haemoglobin A1c (HbA1c) was the most commonly used clinical endpoint. Meta-analytic estimates from systematic reviews generated an average reduction of 0.46% (median 0.40%) of HbA1c in patients with diabetes mellitus who received periodontal treatment. These meta-analyses had, nevertheless, methodological limitations such as inclusion of trials with different types of risk of bias that hinder more robust conclusions. A recent meta-analysis that included recently published large randomized controlled trials did not show significant change in the level of HbA1c at the 6 mo follow-up. The AMSTAR checklist generated results that were more conservative than OQAQ. Findings from this overview do not support the information that periodontal treatment may improve glycaemic control. Methodological issues described in this overview may guide further research on this topic.
Keywords: diabetes mellitus; meta-analysis; overview; periodontitis.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
-
Treatment of periodontal disease for glycaemic control in people with diabetes mellitus.Cochrane Database Syst Rev. 2015 Nov 6;2015(11):CD004714. doi: 10.1002/14651858.CD004714.pub3. Cochrane Database Syst Rev. 2015. Update in: Cochrane Database Syst Rev. 2022 Apr 14;4:CD004714. doi: 10.1002/14651858.CD004714.pub4. PMID: 26545069 Free PMC article. Updated. Review.
-
Does nonsurgical periodontal therapy improve glycemic control?Evid Based Dent. 2023 Mar;24(1):21-22. doi: 10.1038/s41432-023-00860-0. Epub 2023 Mar 8. Evid Based Dent. 2023. PMID: 36890240
-
Effectiveness of periodontal treatment to improve glycemic control: an umbrella review.Acta Diabetol. 2023 Jan;60(1):101-113. doi: 10.1007/s00592-022-01991-z. Epub 2022 Oct 19. Acta Diabetol. 2023. PMID: 36261746
-
An update of the evidence on the potential impact of periodontal therapy on diabetes outcomes.J Clin Periodontol. 2018 Feb;45(2):188-195. doi: 10.1111/jcpe.12836. Epub 2017 Dec 26. J Clin Periodontol. 2018. PMID: 29277978 Review.
-
Effect of non-surgical periodontal therapy on hemoglobin A1c in periodontitis patients without diabetes mellitus: A systematic review and meta-analysis.J Dent. 2024 Jun;145:104974. doi: 10.1016/j.jdent.2024.104974. Epub 2024 Apr 19. J Dent. 2024. PMID: 38642823 Review.
Cited by
-
The impact of metabolic disorders on management of periodontal health in children.Pediatr Discov. 2024 Mar;2(1):e38. doi: 10.1002/pdi3.38. Epub 2023 Nov 3. Pediatr Discov. 2024. PMID: 38784180 Free PMC article.
-
Embracing the future: The evolution of systematic reviews and meta-analyses in periodontology.J Adv Periodontol Implant Dent. 2023 Dec 18;15(2):65-66. doi: 10.34172/japid.2023.025. eCollection 2023. J Adv Periodontol Implant Dent. 2023. PMID: 38357339 Free PMC article. No abstract available.
-
Methodological quality of systematic reviews in dentistry including animal studies: a cross-sectional study.Ir Vet J. 2023 Dec 14;76(1):33. doi: 10.1186/s13620-023-00261-w. Ir Vet J. 2023. PMID: 38098065 Free PMC article.
-
Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis.Healthcare (Basel). 2023 Sep 28;11(19):2649. doi: 10.3390/healthcare11192649. Healthcare (Basel). 2023. PMID: 37830686 Free PMC article. Review.
-
Evaluation of a Digital Decision Support System to Integrate Type 2 Diabetes Mellitus and Periodontitis Care: Case-Vignette Study in Simulated Environments.J Med Internet Res. 2023 Oct 2;25:e46381. doi: 10.2196/46381. J Med Internet Res. 2023. PMID: 37782539 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical