Apelin/APJ system and cancer
- PMID: 27083318
- DOI: 10.1016/j.cca.2016.04.001
Apelin/APJ system and cancer
Abstract
Apelin is an endogenous ligand of the apelin receptor (APJ), a seven-transmembrane G protein-coupled receptor. Apelin/APJ system has a wide tissue distribution in the brain as well as in peripheral organs including heart, lung, vessels, and adipose tissue. Apelin/APJ was involved in regulating cardiac and vascular function, heart development, and vascular smooth muscle cell proliferation. In this article, we summarize the role of apelin/APJ system on lung cancer, gastroesophageal and colonic cancer, hepatocellular carcinoma, prostate cancer, endometrial cancer, oral squamous cell carcinoma, brain cancer, and tumor neoangiogenesis. Apelin/APJ may be a potential anticancer therapeutic target.
Keywords: APJ; Apelin; Cancer; Carcinoma; Vessels.
Copyright © 2016 Elsevier B.V. All rights reserved.
Similar articles
-
Apelin/APJ system: A novel promising therapy target for pathological angiogenesis.Clin Chim Acta. 2017 Mar;466:78-84. doi: 10.1016/j.cca.2016.12.023. Epub 2016 Dec 23. Clin Chim Acta. 2017. PMID: 28025030 Review.
-
The apelin-APJ system induces tumor arteriogenesis in hepatocellular carcinoma.Anticancer Res. 2014 Oct;34(10):5313-20. Anticancer Res. 2014. PMID: 25275024
-
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.J Endocrinol. 2013 Sep 11;219(1):R13-35. doi: 10.1530/JOE-13-0227. Print 2013 Oct. J Endocrinol. 2013. PMID: 23943882 Review.
-
Biology of the apelin-APJ axis in vascular formation.J Biochem. 2012 Aug;152(2):125-31. doi: 10.1093/jb/mvs071. Epub 2012 Jun 28. J Biochem. 2012. PMID: 22745157
-
Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes.FASEB J. 2008 Dec;22(12):4146-53. doi: 10.1096/fj.07-104018. Epub 2008 Aug 15. FASEB J. 2008. PMID: 18708591
Cited by
-
Expression of the apelin receptor, a novel potential therapeutic target, and its endogenous ligands in diverse stem cell populations in human glioblastoma.Front Neurosci. 2024 May 13;18:1379658. doi: 10.3389/fnins.2024.1379658. eCollection 2024. Front Neurosci. 2024. PMID: 38803685 Free PMC article.
-
Role of Angiogenesis and Its Biomarkers in Development of Targeted Tumor Therapies.Stem Cells Int. 2024 Jan 4;2024:9077926. doi: 10.1155/2024/9077926. eCollection 2024. Stem Cells Int. 2024. PMID: 38213742 Free PMC article. Review.
-
Single-cell RNA sequencing of human prostate basal epithelial cells reveals zone-specific cellular populations and gene expression signatures.J Pathol. 2024 Feb;262(2):212-225. doi: 10.1002/path.6227. Epub 2023 Nov 20. J Pathol. 2024. PMID: 37984408
-
The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer.Cells. 2023 Apr 9;12(8):1118. doi: 10.3390/cells12081118. Cells. 2023. PMID: 37190027 Free PMC article. Review.
-
Significance of Serum Apelin Levels as a Biomarker for Gastric Cancer Diagnosis.Asian Pac J Cancer Prev. 2023 Mar 1;24(3):827-831. doi: 10.31557/APJCP.2023.24.3.827. Asian Pac J Cancer Prev. 2023. PMID: 36974534 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources