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Review
. 2016 Dec;64(6):443-454.
doi: 10.1007/s00005-016-0394-x. Epub 2016 May 13.

Adipose-Derived Stem Cells as a Tool in Cell-Based Therapies

Anna Bajek  1 , Natalia Gurtowska  2 , Joanna Olkowska  2 , Lukasz Kazmierski  2 , Malgorzata Maj  2 , Tomasz Drewa  2   3
Affiliations
Review

Adipose-Derived Stem Cells as a Tool in Cell-Based Therapies

Anna Bajek et al. Arch Immunol Ther Exp (Warsz). 2016 Dec.

Abstract

Recent development in stem cell isolation methods and expansion under laboratory conditions create an opportunity to use those aforementioned cells in tissue engineering and regenerative medicine. Particular attention is drawn towards mesenchymal stem cells (MSCs) being multipotent progenitors exhibiting several unique characteristics, including high proliferation potential, self-renewal abilities and multilineage differentiation into cells of mesodermal and non-mesodermal origin. High abundance of MSCs found in adipose tissue makes it a very attractive source of adult stem cells for further use in regenerative medicine applications. Despite immunomodulating properties of adipose-derived stem cells (ASCs) and a secretion of a wide variety of paracrine factors that facilitate tissue regeneration, effectiveness of stem cell therapy was not supported by the results of clinical trials. Lack of a single, universal stem cell marker, patient-to-patient variability, heterogeneity of ASC population combined with multiple widely different protocols of cell isolation and expansion hinder the ability to precisely identify and analyze biological properties of stem cells. The above issues contribute to conflicting data reported in literature. We will review the comprehensive information concerning characteristic features of ASCs. We will also review the regenerative potential and clinical application based on various clinical trials.

Keywords: Adipose tissue; Adipose-derived stem cells; Clinical trials; Regenerative medicine.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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