Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus
- PMID: 27181765
- PMCID: PMC4931192
- DOI: 10.1111/jdi.12441
Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus
Abstract
Diabetes can be simply classified into type 1 diabetes mellitus and type 2 diabetes mellitus. Zinc transporter 8 (ZnT8), a novel islet autoantigen, is specifically expressed in insulin-containing secretory granules of β-cells. Genetic studies show that the genotypes of SLC30A8 can determine either protective or diabetogenic response depending on environmental and lifestyle factors. The ZnT8 protein expression, as well as zinc content in β-cells, was decreased in diabetic mice. Thus, ZnT8 might participate in insulin biosynthesis and release, and subsequently involved deteriorated β-cell function through direct or indirect mechanisms in type 1 diabetes mellitus and type 2 diabetes mellitus. From a clinical feature standpoint, the prevalence of ZnT8A is gradiently increased in type 2 diabetes mellitus, latent autoimmune diabetes in adults and type 1 diabetes mellitus. The frequency and epitopes of ZnT8-specific T cells and cytokine release by ZnT8-specific T cells are also different in diabetic patients and healthy controls. Additionally, the response to ZnT8 administration is also different in type 1 diabetes mellitus and type 2 diabetes mellitus. In the present review, we summarize the literature about clinical aspects of ZnT8 in the pathogenesis of diabetes, and suggest that ZnT8 might play a different role between type 1 diabetes mellitus and type 2 diabetes mellitus.
Keywords: Type 1 diabetes mellitus; Type 2 diabetes mellitus; Zinc transporter 8.
© 2015 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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References
-
- Tuomi T, Santoro N, Caprio S, et al The many faces of diabetes: a disease with increasing heterogeneity. Lancet 2014; 383: 1084–1094. - PubMed
-
- Xiang YF, Zhao YJ, Zhou ZG. Latent autoimmune diabetes in adults: evidences for diabetes spectrum? Chin Med J (Engl) 2013; 126: 783–788. - PubMed
-
- Liu L, Li X, Xiang Y, et al Latent autoimmune diabetes in adults with low‐titer GAD antibodies: similar disease progression with type 2 diabetes: a nationwide, multicenter prospective study (LADA China Study 3). Diabetes Care 2015; 38: 16–21. - PubMed
-
- Lin J, Zhou ZG, Wang JP, et al From Type 1, through LADA, to type 2 diabetes: a continuous spectrum? Ann N Y Acad Sci 2008; 1150: 99–102. - PubMed
-
- Brooks‐Worrell B, Palmer JP. Is diabetes mellitus a continuous spectrum? Clin Chem 2011; 57: 158–161. - PubMed
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