Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs

doi:10.1016/j.tig.2016.08.004

Review

. 2016 Oct;32(10):620-637.

doi: 10.1016/j.tig.2016.08.004. Epub 2016 Sep 1.

Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs

Bethany Signal¹, Brian S Gloss¹, Marcel E Dinger²

Affiliations

¹ Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, Australia.
² Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, Australia. Electronic address: m.dinger@garvan.org.au.

PMID: 27592414
DOI: 10.1016/j.tig.2016.08.004

Review

Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs

Bethany Signal et al. Trends Genet. 2016 Oct.

. 2016 Oct;32(10):620-637.

doi: 10.1016/j.tig.2016.08.004. Epub 2016 Sep 1.

Authors

Bethany Signal¹, Brian S Gloss¹, Marcel E Dinger²

Affiliations

¹ Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, Australia.
² Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, Australia. Electronic address: m.dinger@garvan.org.au.

PMID: 27592414
DOI: 10.1016/j.tig.2016.08.004

Abstract

Although a considerable portion of eukaryotic genomes is transcribed as long noncoding RNAs (lncRNAs), the vast majority are functionally uncharacterised. The rapidly expanding catalogue of mechanistically investigated lncRNAs has provided evidence for distinct functional subclasses, which are now ripe for exploitation as a general model to predict functions for uncharacterised lncRNAs. By utilising publicly-available genome-wide datasets and computational methods, we present several developed and emerging in silico approaches to characterise and predict the functions of lncRNAs. We propose that the application of these techniques provides valuable functional and mechanistic insight into lncRNAs, and is a crucial step for informing subsequent functional studies.

Keywords: computational methods; functional mechanisms.; lncRNA; regulation.

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Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs

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Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs

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