The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis

doi:10.3390/ph3030482

Review

. 2010 Mar 8;3(3):482-513.

doi: 10.3390/ph3030482.

The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis

Domenico Ribatti¹

Affiliations

Affiliation

¹ Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari, Italy. ribatti@anatomia.uniba.it.

PMID: 27713265
PMCID: PMC4033966
DOI: 10.3390/ph3030482

Review

The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis

Domenico Ribatti. Pharmaceuticals (Basel). 2010.

. 2010 Mar 8;3(3):482-513.

doi: 10.3390/ph3030482.

Author

Domenico Ribatti¹

Affiliation

¹ Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari, Italy. ribatti@anatomia.uniba.it.

PMID: 27713265
PMCID: PMC4033966
DOI: 10.3390/ph3030482

Abstract

Antiangiogenesis, e.g., inhibition of blood vessel growth, is being investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological inhibition interferes with the angiogenic cascade or the immature neovasculature with synthetic or semi-synthetic substances, endogenous inhibitors or biological antagonists.The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane, which serves as a gas exchange surface and its function is supported by a dense capillary network. Because its extensive vascularization and easy accessibility, CAM has been used to study morphofunctional aspects of the angiogenesis process in vivo and to study the efficacy and mechanism of action of pro- and anti-angiogenic molecules. The fields of application of CAM in the study of antiangiogenesis, including our personal experience, are illustrated in this review article.

Keywords: antiangiogenesis; chorioallantoic membrane; tumor progression.

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References

1. Ribatti D., Nico B., Crivellato E., Roccaro A.M., Vacca A. The history of the angiogenic switch concept. Leukemia. 2007;21:44–52. - PubMed
1. Folkman J. Tumor angiogenesis: Therapeutic implications. New Engl. J. Med. 1971;285:1182–1186. - PubMed
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[1] Ribatti D., Nico B., Crivellato E., Roccaro A.M., Vacca A. The history of the angiogenic switch concept. Leukemia. 2007;21:44–52. - PubMed

[2] Ribatti D., Nico B., Crivellato E., Roccaro A.M., Vacca A. The history of the angiogenic switch concept. Leukemia. 2007;21:44–52. - PubMed

[3] Folkman J. Tumor angiogenesis: Therapeutic implications. New Engl. J. Med. 1971;285:1182–1186. - PubMed

[4] Folkman J. Tumor angiogenesis: Therapeutic implications. New Engl. J. Med. 1971;285:1182–1186. - PubMed

[5] Nyberg P., Xie L., Kalluri R. Endogenous inhibitors of angiogenesis. Cancer Res. 2005;65:3967–3979. doi: 10.1158/0008-5472.CAN-04-2427. - DOI - PubMed

[6] Nyberg P., Xie L., Kalluri R. Endogenous inhibitors of angiogenesis. Cancer Res. 2005;65:3967–3979. doi: 10.1158/0008-5472.CAN-04-2427. - DOI - PubMed

[7] Ellis L.M. Bevacizumab. Nat. Rev. Drug Discov. 2005:S8–S9. - PubMed

[8] Ellis L.M. Bevacizumab. Nat. Rev. Drug Discov. 2005:S8–S9. - PubMed

[9] Norrby K. In vivo models of angiogenesis. J. Cell. Mol. Med. 2006;10:588–612. doi: 10.1111/j.1582-4934.2006.tb00423.x. - DOI - PMC - PubMed

[10] Norrby K. In vivo models of angiogenesis. J. Cell. Mol. Med. 2006;10:588–612. doi: 10.1111/j.1582-4934.2006.tb00423.x. - DOI - PMC - PubMed

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The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis

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The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis

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